2016, Number 4
Rev Cubana Hematol Inmunol Hemoter 2016; 32 (4)
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ABSTRACTSickle cell anaemia (SCD) is a disorder with a high index of morbidity, affecting the quality of life of these patients. Priapism is a common complication of SCD and it is characterized by a prolonged and persistent erection of the penis lasting more than 4 hours without associated sexual stimulation. The 95 % of priapism crisis in SCD patients are ischemic type. In this paper we review the new molecular mechanisms implicated in the pathogenesis of ischemic priapism and provide the basis for potential future therapies.