2016, Number 4
Longitudinal ecocardiographic assesment in patients with acute lymphoid leukemia that received anthracyclines during childhood
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ABSTRACTIntroduction: Cancer therapy could cause frequent cardiac toxicity, so we decided to perform an echocardiographic longitudinal study of the late effects caused by anthracyclines administration in patients that were treated for acute lymphoid leukemia during childhood.
Methods: All the patients admitted in the Pediatric Service of Institute of Hematology and Immunology, with acute lymphoid leukemia since april 2002 until february 2015 and that have at least two echocardiographic studies after finishing therapy. A complete physical exammination was performed to all of them and the cumulative dose of anthracyclines received was calculated and also time until evaluation. From the echocardiograms were taken the measurements of left auricle, right ventricle, ejection fraction and shortening fraction.
Results: the main findings were signs of late subclinical cardiotoxicity with a mean of 9 years after therapy completion and there were no sex predominance. In the first echocardiogram performed three years after stopping therapy there were more alterations in the measures of left auricle and right ventricle. The studies were repeated every three years and in the third one there were more alterations in ejection fraction and shortening fraction and there also were a statiscally significative relation between cumulative anthracyclines doses and echocardiographic findings.
Conclusions: There were found subclinical cardiac dysfunction that increases as time goes by.
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