medigraphic.com
ISSN 1561-3119 (Electronic)

2017, Number 1

<< Back Next >>

Rev Cubana Pediatr 2017; 89 (1)

Gastrointestinal stromal tumor

Verdecia CC, Villamil MR, Montero RI, Pineda FD

Language: Spanish
References: 15
Page: 53-59
PDF size: 89.98 Kb.


ABSTRACT

Introduction: the gastrointestinal stromal tumor is a rare pediatric tumor that is generally located in the stomach in 50 % of patients, followed by the location in the small intestines. It is even rarer in the large intestine as well as in the esophagus. It may range from a benign to a malignant form of the disease. There is a large number of predisposing factors, but great importance is attached to hereditary predisposition and mutations and is also associated to type 1 neurofibromatosis. Its clinical manifestations are occult digestive bleeding, anemia and vomiting. Digestive upsets and abdominal pain were described.
Case presentation: this is the case of a male, mixed race patient aged 15 years, who presented with a stromal tumor in the posterior gastric wall at the level of major curvature, very close to the pylorus. The tumor was surgically resected through laparotomy, but the initial diagnosis and the biopsy taking was made by way of minimal access surgery. The patient is under close follow-up.
Conclusions: there are few cases that have been published about gastrointestinal stromal tumor in pediatrics and the importance of surgery for the control of this disease is underlined.


REFERENCES

  1. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33(5):459-65.

  2. Martín-González MA, Fuentes Valdés E, Artiles Ivonet J, Solares María E, Martín- González AE, Lima M. Tumor del estroma gastrointestinal y cirugía. Rev Cubana Cir [serie en Internet]. 2008 Dic [citado 28 de Junio de 2016];47(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 74932008000300012&lng=es&nrm=iso&tlng=es

  3. Shimomura M, Ikeda S, Takakura Y, Kawaguchi Y, Tokunaga M, Takeda H, et al. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review. Pediatr Surg Int. 2010;26(6):649-54.

  4. Joensuu H, Vehtari A, Riihimäki J. Risk of recurrence of gastrointestinal stromal tumor after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. 2012;13(3):265-74.

  5. Kindblom LG, Remotti HE, Aldenborg F. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998;152(5):1259-69.

  6. Corless CL, Heinrich MC. Molecular pathobiology of gastrointestinal stromal sarcomas. Annu Rev Pathol. 2008;3:557-86.

  7. Miettinen M, Lasota J. gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130(10):1466-78.

  8. Heinrich MC, Corless CL, Duensing A. PEDFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299(5607):708-10.

  9. Joensuu H, Eriksson M, Sundby HK. One vs. three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA. 2012;307(12):1265-72.

  10. Gaal J, Stratakis CA, Carney JA. SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. Mod Pathol. 2011;24(1):147-51.

  11. Gatta G, van der Zwan JM, Casali PG. Rare cancers are not so rare: the rare cancer burden in Europe. Eur J Cancer. 2011;47(17):2493-511.

  12. Demetri GD. Gastrointestinal stromal tumor. In: De Vita VT Jr., Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. p. 1060-7.

  13. Martel C, Forman D, Plummer M. Gastric cancer: Epidemiology and risk factors. Gastroenterol Clin North Am. 2013 Jun;42(2):219-40.

  14. Mussi C, Ronellenfitsch U, Jakob J. Post-Imatinib surgery in advanced/metastatic GIST: is it worthwhile in all patients? Ann Oncol. 2010;21:403-8.

  15. Demetri GD, Van Oosterom AT, Garret CR. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumors after failure of imatinib: a randomized controlled trial. Lancet. 2006;368(9544):1329-38.




2020     |     www.medigraphic.com