medigraphic.com
SPANISH

Anales Médicos de la Asociación Médica del Centro Médico ABC

ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2017, Number 2

<< Back Next >>

An Med Asoc Med Hosp ABC 2017; 62 (2)

Fecal microbiota transplantation: standardization protocol for donor screening

Núñez MME, Cebada LM, Contreras PB
Full text How to cite this article

Language: Spanish
References: 10
Page: 114-119
PDF size: 217.25 Kb.


Key words:

Fecal microbiota transplant, Clostridium difficile, pseudomembranous colitis.

ABSTRACT

Background: The human intestine’s microbiota prevents the presence of pathogens, and it is involved in metabolic and immune system modulation. Fecal microbiota transplant is a procedure that requires a standardization process regarding donor selection. Problem: There is not a standardized method for donor selection in microbiota fecal transplant. Objectives: To analyze the methods of donor selection in past procedures (laboratory test/physical examination/questionnaires) in order to propose and develop a standardization protocol for donor screening. Design: Access to the internal computer network of medical records at ABC Hospital, Mexico. To develop a retrospective analysis of fecal microbiota transplant receptor records and donor selection methods. To perform a standardized protocol for donor selection. Results: Four fecal microbiota transplant procedures have been developed since 2013; the screening method was only through laboratory tests and none considered a method of screening for donors. Conclusions: Due to the lack of a standardized donor selection process, implementation of a questionnaire as a method of screening donors is necessary, as mentioned by R. Collen. Recommendations: A questionnaire aimed at the detection of the main risk factors associated with fecal microbiota transplant was developed.


REFERENCES

  1. Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A et al. Update on fecal microbiota transplantation 2015: indications, methodologies, mechanisms, and outlook. Gastroenterology. 2015; 149 (1): 223-237.

  2. The Fecal Transplant Foundation: Awareness and support for fecal microbiota transplant [sede web]. Indiana: The Fecal Transplant Foundation; 2016 [acceso 06/02/2016]. What is FMT. Available in: http://thefecaltransplantfoundation.org/what-is-fecal-transplant/.

  3. Moore T, Rodriguez A, Bakken JS. Fecal microbiota transplantation: a practical update for the infectious disease specialist. Clin Infect Dis. 2014; 58 (4): 541-545.

  4. Hevia A, Delgado S, Margolles A, Sánchez B. Application of density gradient for the isolation of the fecal microbial stool component and the potential use thereof. Sci Rep. 2015; 5: 16807.

  5. OpenBiome [sede web]. Boston: Openbiome org.; 2016 [acesso 06/02/2016]. What is fecal microbiota transplantation? Available in: http://www.openbiome.org/about-fmt.

  6. Drekonja D, Reich J, Gezahegn S, Greer N, Shaukat A, MacDonald R et al. Fecal microbiota transplantation for Clostridium difficile infection: a systematic review. Ann Intern Med. 2015; 162 (9): 630-638.

  7. Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol. 2011; 9 (12): 1044-1049.

  8. Vyas D, Aekka A, Vyas A. Fecal transplant policy and legislation. World J Gastroenterol. 2015; 21 (1): 6-11.

  9. Paramsothy S, Borody TJ, Lin E, Finlayson S, Walsh AJ, Samuel D et al. Donor recruitment for fecal microbiota transplantation. Inflamm Bowel Dis. 2015; 21 (7): 1600-1606.

  10. American Gastroenterological Association [sede web]. Bethesda (MD): American Gastroenterological Association; 2013 [acceso 06/02/2016]. Joint Society Letter to FDA - Current Consensus Guidance and Donor Screening and Stool Testing for FMT. Available in: http://www.gastro.org/research/Joint_Society_FMT_Guidance.pdf.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

An Med Asoc Med Hosp ABC. 2017;62