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2017, Number 2

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Correo Científico Médico 2017; 21 (2)

Presentation of a patient with prostate neuroendocrine adenocarcinoma

Pupo RA, Arias AD, Ayón TY, Grass HN
Full text How to cite this article

Language: Spanish
References: 9
Page: 613-619
PDF size: 381.54 Kb.


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ABSTRACT

Prostate cancer commonly affects men after age 50; the evolution is slow, with histological variety of adenocarcinoma present in approximately 95%. It is not frequent to find histological differentiations of neuroendocrine type. A 29-year-old man from Banes was presented with perineal pain and discomfort during the sexual intercourse. The patient was assisted at Urology Consultation of the Lenin Hospital in Holguín where he was treated as a prostatic inflammatory process and antimicrobial and anti-inflammatory drugs were used. Other studies were not obtained and the prostate specific antigen reported high values; rectal examination revealed changes in consistency, a prostate biopsy was suggested, revealing a neuroendocrine adenocarcinoma of the prostate. When consulting the literature, specific therapeutic protocols were not available for these cases, but generally etoposide and cisplatin were used. The evolutions was torpid and rapid the appearance of bone, hepatic, mediastinal and ascites metastases as well as respiratory distress until the patient´s death, at 19 months the diagnosis was defined.


REFERENCES

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  2. Glück G, Mihai M, Stoica R, Andrei R, Sinescu I. Prostate cancer with neuroendocrine differentiation-case report. J Med Life. 2012[citado 26 mar 2017]; 5(1):101-104. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307067/pdf/JMedLife-05-101.pdf

  3. Epstein JI1, Amin MB, Beltran H, Lotan TL, Mosquera JM, Reuter VE, et al. Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. Am J Surg Pathol. 2014[citado 27 mar 2017]; 38(6):756-767. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112087/

  4. Arenas Reyes NJ, Manuel Moreno LA, Carrillo Rodríguez AP, Fonseca Buitrago CL, Daza Almendrales FP. Diferenciación neuroendocrina en cáncer de próstata. Revisión de la literatura. Rev Urol Colombiana. 2014[citado 26 mar 2017]; 23(1):39-43. Disponible en: http://www.redalyc.org/html/1491/149131193008/

  5. Wang HT, Yao YH, Li BG, Tang Y, Chang JW, Zhang J. Neuroendocrine Prostate Cancer (NEPC) Progressing From Conventional Prostatic Adenocarcinoma: Factors Associated With Time to Development of NEPC and Survival From NEPC Diagnosis—A Systematic Review and Pooled Analysis. J Clin Oncol. 2014[citado 27 mar 2017]; 32(30): 3383-3390. Disponible en: http://ascopubs.org/doi/abs/10.1200/jco.2013.54.3553

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  8. Agüero Gómez JL, Cepero Olivera PJ, Duarte Vilariño A, García Cepero D. Microcitoma de próstata o tumor de células pequeñas. Un nuevo reporte. MEDICIEGO. 2014[citado 27 mar 2017]; 20(Supl 1). Disponible en: http://bvs.sld.cu/revistas/mciego/vol20_Supl%201_14/casos/T13.html

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Correo Científico Médico. 2017;21