2004, Number 3
Prevalence of human herpes virus 4 (EBV) and 6 (HHV-6) in Hodgkin’s lymphoma, in patients estudied in Mexico City
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ABSTRACTHodgkin’s lymphoma (HL) constitutes a heterogeneous group of diseases that differe in their clinical course, morphology, immunophenotype, as well as in their relation to the human herpes virus types 4 and 6 . We studied the frequency and location of both viruses in Hodgkin’s lymphomas in 84 patients and compared our results with those of other studies done in health institutions in Mexico City. EBV was present in 54 cases (64.2%) in Hodgkin and Reed-Sternberg cells, and occasionally in lymphocytes and histiocytes. HHV-6 was found in 14 cases (16.6%) in lymphocytes and histiocytes and occasionally in Hodgkin and Reed-Sternberg cells. Both viruses were present in 10 patients (11.9%), 6 with HL of mixed cell type samples and 4 with nodular sclerosis HL. Cell proliferation markers such as Ki 67 (Mib1) was found in Hodgkin and Reed-Sternberg cells in 78 cases (92.8%), and occasionally in histiocytes and lymphocytes. The apoptosis marker p53 was detected in 71 cases (84.5%) mostly in histiocytes and lymphocytes, and occasionally in neoplasic cells.
Epstein MA, Achong BG, Barr YM. Virus particles in cultures lymphoblasts from Burkitt´s lymphoma. Lancet 1964; 1: 702.
Craig FE, Gulley ML, Banks PM. Postransplantation lymphoproliferative disorders. Am J Clin Phatol 1993; 99: 265-271.
Kanavaros P, de Bruin PC, Briere J, Meijer CJLM, Gaulard P. Epstein-Barr virus (EBV) in extranodal T-cell non-Hodgkin´s lymphoma (T-NHL). Identification of nasal T-NHL as a distinct clinocopathological entity associated with EBV. Leukem Lymphoma 1995; 18: 27-34.
Anagnostopoulos I, Hummel M. Epstein-Barr virus in tumours. Histopathology 1996; 29: 297-315.
Quintanilla ML, Gamboa DA, Goméz-Ledezma I et al. Association of Epstein-Barr virus latent membrane protein and Hodgkin¨s disease in México. Mod Pathol 1995; 8: 675-679.
Zarate OA, Roman LN, Kingma DW et al. Hodgkin ‘s disease in Mexico. Prevalence of Epstein-Barr virus sequences and correlation with histologic subtype. Cancer 1995; 75: 1360-1366.
Ambinder RF, Browning PJ, Lorenzana I et al. Epstein-Barr virus and childhood Hodgkin’s disease in Honduras and the United States. Blood 1993; 81: 462-467.
Yamanishi K, Okuno T, Shiraki, Takahashi M, Asano Y, Kurata T. Identification of human herpesvirus 6 as casual agent for exanthem subitum. Lancet 1988; 1: 1065.
Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Norni F et al. Human Herpesvirus-6 in human lymphomas: Identification of specific sequences in Hodgkin’s Lymphomas by polymerasa chain reaction. Blood 1991; 77: 10; 2251-2258.
Dirnhofer S, Angeles AA, Ortiz-H C, Reyes E, Gredler E et al. High prevalence of a 30 base pair deletion in the Epstein-Barr virus (EBV) latent membrane protein 1 Gene and of strain type B EBV in mexican classical Hodgkin’s disease and reactive lymphoid tissue. Human Pathology 1999; 30: 781-787.
Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, Macdonald S, Pulford KAF, Stein H, Mason DY. Immunoenzymatic labeling of monoclonal anbodies using Immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP- complexes). J Histochem Cytochem 1984; 32: 219-229.
Krueger GRF, Sievert J, Juecker M, Tesch H, Diehl V, Ablashi DV, Balachandran N, Luka J. Hodgkin’s cells express human herpesvirus 6 antigens. J Viral Dis 1992; 1: 15-23.
Seyda M, Scheele T, Neumann R, Krueger GRF. Comparative evaluation of non-radioactive in situ hybridization for pathologic diagnosis of viral infection. Path Res Pract 1989; 184: 18-26.
Chang KL, Albajar PF, Chen Y-Y, Johnson RM, Weiss LM. High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin’s disease ocurring in Peru. Blood 1993; 81: 496-499.
Cordova Perez FJ, Gonzalez-Keelan CI, Velez R. Epstein-Barr virus in biopsies from patients with Hodgkin and non Hodgkin lymphoma at the University of Puerto Rico immunohistochemistry laboratory. PR Health Sci J 2003; 22 (2): 125-129.
Flavell KJ, Billingham LJ, Biddulph JP, Gray Lay, Flavell JR, Constandinou CM et al. The effect of Epstein-Barr virus status on outcome in age-and sex-defined subgroups of patients with advance Hodgkin’s disease. Ann Oncol 2003; 14 (2): 282-290.
Armstrong A, Jarret R, Lennard A, Proctor S, Angus B. Hodgkin’s disease and EBV: Prognostic significance of EBV positivity. J Pathol, 1992; 167: 124.
Vestlev PM, Pallesen G, Sandvej K, Hamilton-Dutoit SJ, Bendtzen SM. Prognosis of Hodgkin’s disease is not influenced by Epstein-Barr virus latent membrane protein (letter). Int J Cancer 1992; 50: 670.
Niller HH, Salamon D, Ng K, Koroknai A, Banati F, Bauml G et al. The in vivo binding site for oncoprotein-cMyc in the promoter for Epstein-Barr virus (EBV) encoding RNA (EBER) 1 suggests a specific role for EBV in lymphomagenesis. Med Sci Monit 2003; 9 (1): 1-9.
Serraino D, Franceschi S, Talamini R, Barra S, Negri E, Carbone A, La Vecchi C: Socioeconomic indicators, infectious disease and Hodgkin’s disease. Int J Cancer 1991; 47: 352.
Boyle MJ, Vasak E, Tschuchnigg M, Turner JJ, Sculley T, Pennny R et al. Subtypes of Epstein-Barr virus (EBV) in Hodgkin’s disease: Association between B-type EBV and immunocompromise. Blood 1993; 81: 468.
Luppi M, Marasca R, Barozzi P, Artusi T, Torelli G. Frequent detection of human herpesvirus-6 sequences by polymerasa chain reaction in paraffin-embedded lymph nodes from patients with angioimmunoblastic lymphadenopathy-like lymphoma. Leuk Res 1993; 17: 1003-1011.
Josephs SF, Buchbinder A, streicher HZ, Ablashi DV, Salahuddin SZ, Guo H-G et al. Detection of human B lymphotropic virus (human herpesvirus 6) sequences in B lymphoma tissues of three patients. Leuk 1988; 2: 496-502.