Picado LLN, Cob GA

Language: Spanish
References: 7
Page: 1-7
PDF size: 562.92 Kb.

ABSTRACT

Osmotic demyelination syndrome (ODS) refers to central pontine myelinolysis and extrapontine myelinolysis; this disorder is caused by injury of the myelin sheath and white matter tracts. Clinical manifestations are diverse, being the main factor associated hyponatremia; however, it has been associated to some other conditions. We present the case of a patient with hypopituitarism, who developed symptomatic hyponatremia secondary to the use of tiazides, fluoxetine, carbamazepine and abrupt suspension of steroid chronic use, sodium was quickly restored; resulting in ODS.

REFERENCES

1. Alleman A. Osmotic Demyelination Syndrome: Central Pontine Myelinolysis and Extrapontine Myelinolysis. Semin Ultrasound CT MRI, 2014; 35:153-159

2. Norenberg MD. Central pontine myelinolysis: historical and mechanistic considerations Metab Brain Dis. 2010;25(1):97-106.

3. Singh T Fugate J Rabinstein A. Central pontine and extrapontine myelinolysis: a systematic review. European Journal of Neurology. 2014.;21:1443-1450.

4. Hurley R Filley C Taber K. Central pontine myelinolysis: a metabolic disorder of myelin, J Neuropsychiatry Clin Neurosci. 2011;23(4):369-374.

5. Graff-Radford J Fugate J Kaufmann T et al. Clinical and Radiologic Correlations of Central Pontine Myelinolysis Syndrome, Mayo Clin Proc. 2011;86(11):1063-1067.

6. Kallakatta R Radhakrishnan A Fayaz R et al. Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome (central pontine and extrapontine myelinolysis) in 25 patients. J Neurol Neurosurg Psychiatry. 2011;82(3):326-331.

7. Mohmand HK Issa D Ahmad Z et al. Hypertonic saline for hyponatremia: risk of inadvertent overcorrection. Clin J Am Soc Nephrol. November 2007;2(6):1110-1117.