2017, Number 1
Determination of levels of IL-23 soluble receptor in serum and plasma of patients with chronic and aggressive periodontitis
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ABSTRACTPeriodontitis is a chronic immunologic-inflammatory disease primarily caused by Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. The most common types of periodontal disease are: chronic (CP) and aggressive (AP) which are characterized by gingival inflammation, formation of periodontal pockets, and loss of insertion and destruction of alveolar bone. However, attachment loss and tissue destruction is faster in AP than CP. Dendritic cells are stimulated by periodontopathogenic bacterias and produce IL-23; this cytokine binds to its specific receptor (IL-23R) trough Th17 cells to induce production of IL-17. It is to be noted that IL-23R can be cleaved and remain as a soluble receptor (IL-23Rs). IL-23 and IL-17 and its receptors indirectly participate in alveolar bone resorption. In this sense, it was found that IL-17 is elevated in patients with CP compared to healthy subjects (HS). However, little has been said about IL-23 and its receptor in periodontitis. Objective: Type of study: descriptive, cross-sectional and analytical. Measuring IL-23Rs levels in serum and plasma of patients with PC, PA and healthy subjects. Material and methods: Serum and plasma were collected from patients with CP (n = 8) and AP (n = 8) as well as from HS (n = 8). The concentration of IL-23Rs was determined by ELISA. Results: There were no significant differences in IL-23Rs between patients with PA and PC compared with SS. However, we found a significant increase in IL-23Rs in the plasma of patients with AP compared to SS. Likewise, we observed a significant increase in PC patients compared with SS. Conclusions: There is an increase in plasma IL-23Rs in patients with PC and PA compared to SS. However, we found no significant differences in serum IL-23Rs between the PC, PA and SS groups.
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