2017, Number 2
Rev Mex Neuroci 2017; 18 (2)
Sanabria-Castro A, Alvarado-Echeverría I, Monge-Bonilla C
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ABSTRACTAcetylcholine was discovered in 1921 and was the first monoamine described with neurotransmission functions. The cholinergic transmission comprises all the synapses where acetylcholine is the main neurotransmitter. Acetylcholine can have both excitatory and inhibitory actions through its two main receptors: nicotinic and muscarinic. It exerts diverse effects and functions including motor, neuroendocrine, parasympathetic and sensorial. In spite of the recent advances in the understanding of the central cholinergic neurotransmission, limitations still exist both at nicotinic and muscarinic levels. The main purpose of this review is to describe key molecular aspects regarding central cholinergic neurotransmission.