Gutiérrez-Aguilar M, Corona PN

Language: Spanish
References: 15
Page: 91-96
PDF size: 405.73 Kb.

ABSTRACT

Mammalian mitochondria express a structurally unidentified unselective channel termed the Mitochondrial Permeability Transition Pore. Studies designed to determine the protein structure of this pore have been scarce mainly due to difficulties in generating knock out organisms of potential pore components. In this scenario, baker´s yeast (Saccharomyces cerevisiae) represents an appealing alternative since it harbors a pore with similar characteristics. Given the available genetic tools as well as the possibility for this yeast to grow with dysfunctional mitochondria for oxidative phosphorylation, S. cerevisiae represents an attractive model to study the molecular structure of the mitochondrial permeability transition pore.

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