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2017, Number 3

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Rev Clin Esc Med 2017; 7 (3)

Actualidad en el uso de la terapia dual de antiagregación plaquetaria con aspirina y clopidogrel en el manejo agudo de enfermedad cerebrovascular

Sequeira QCM, Villegas RJD

Language: Spanish
References: 30
Page: 11-21
PDF size: 272.18 Kb.


ABSTRACT

Cerebrovascular disease is a leading cause of disability and death worldwide. A key aspect in the approach of these patients is secondary prevention, following a transitory ischemic attack and ischemic stroke. In those patients with contraindication for thrombolytic treatment, platelet antiaggregation will be the main therapeutic resource used. National and international guidelines include among their recommendations only aspirin monotherapy, however recent studies conclude that dual therapy with clopidogrel and aspirin initiated 12 hours after the onset of symptoms is more effective and doesn’t increase the incidence of hemorrhage, evaluating patients both 90 and 365 days after the ischemic event. Those benefits are cost-effective. The generalized incorporation of these results and the final results of the POINT study could represent a shift in the treatment paradigm.


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