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Academia Mexicana de Neurología, A.C.

2017, Number 3

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Rev Mex Neuroci 2017; 18 (3)

Effects of age-dependent environmental enrichment on behavior, cognitive function and neurochemical features

Mora-Gallegosaa A, Salasa S, Fornaguera TJ

Language: Spanish
References: 46
Page: 66-78
PDF size: 168.53 Kb.


ABSTRACT

Aging is associated with cognitive decline, which includes detrimental effects on learning and memory. It has been suggested that environmental enrichment may help to prevent the age-dependent declining, but there are contradictory results. This may be due, at least in part, to the wide spectrum of protocols of environmental enrichment used, but in particular to the age at which the enrichment starts. It has been reported that young animals may profit more from the environmental enrichment than mature ones at behavioral and neurochemical levels. Nevertheless, in our study, young and mature adult rats were submitted to environmental enrichment and both groups showed specific differences in habituation to a novel environment, working and reference memory in a spatial task. Young rats are clearly more active in a novel environment and radial maze test, compared to mature rats. Cognitive strategies related to working and reference memory were evaluated with radial maze test, and our results show that mature and young rats have different strategies to solve tasks, although young enriched rats have a better performance on this test. These results are correlated with DA turnover in ventral striatum (VS) and glutamate and GABA in hippocampus. Based in our results, earlier developmental periods are shown to be more sensitive to environmental enrichment, and on the other side, the cautiousness showed by mature rats seems to be an effective strategy to solve reference and working memory tasks.


REFERENCES

  1. Kandel E., Schwartz, J., (2001) Thomas J. Principles of Neural Science. Spain: Mc Graw Hill.

  2. Mora, F., Segovia, G., Del Arco, A. (2007) Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain. Brain Research Reviews; 55: 78–88.

  3. Rozenweig, ES., Bennett, EL. (1996) Psychobiology of plasticity: effects of training and experience on brain and behavior. Behavioral Brain Research; (78) 1: 57-65

  4. Brenes, J., Padilla, M., Fornaguera, J. (2009). A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats. Behavioral Brain Research; 197: 125–37.

  5. Simpson, J., Kelly, J. P. (2011) The impact of environmental enrichment in laboratory ratsbehavioural and neurochemical aspects. Behavioral Brain Research; 222: 246–264.

  6. Carrillo-Mora P, Giordano M, Santamaría A. (2009) Spatial memory: Theoretical basis and comparative review on experimental methods in rodents. Behav. Brain Research; 203: 151-164.

  7. Mora-Gallegos, A., Rojas-Carvajal, M., Salas, S., Saborío-Arce, A. Fornaguera, J., & Brenes, JC. (2015) Age-dependent effects of environmental enrichment on spatial memory and neurochemistry. Neurobiology of learning and memory; 96-104

  8. Segovia, G., Del Arco, A., Mora, F. (2009) Environmental enrichment, prefrontal cortex, stress, and aging of the brain. Journal of Neural Transmission; 116: 1007-1016.

  9. Mohammed, A., Zhu, S., Darmopil, S., Hjerling, J., et al. (2002) Environmental enrichment and the brain. Progress in Brain Research; 138: 109-133.

  10. Florian, C., Roullet P. (2004) Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice. Behavioural Brain Research; 154: 365-74.

  11. Myhrer, T. (2003) Neurotransmitter systems involved in learning and memory in the rat: a metaanalysis based on studies of four behavioral tasks. Brain Res. Rev.; 41: 268-287.

  12. Leggio, J. G., Mandolesi, L., Federico, F., et al. (2005) Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behavioral Brain Research; 163: 78–90.

  13. Bennett, J. C., McRae, P. A., Levy, L. J., & Frick, K. M. (2006). Long-term continuous, but no daily, environmental enrichment reduces spatial memory decline in aged male mice. Neurobiology of Learning and Memory, 85: 139–152.

  14. Harburger, L. L., Lambert, T. J., & Frick, K. (2007) Age-dependent effects of environmental enrichment on spatial reference memory in male mice. Behavioral Brain Research; 185, 43–48.

  15. Foster, TC. (2012). Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity. Prog. Neurobiol; 96 (3): 283-303.

  16. Bizon, JL., LASarge, CL., Montgomery, KS, et al. (2009) Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiology of Aging; 30 (4): 646-655

  17. Bowman, R. E., Beck, K. D., & Luine, V. N. (2003). Chronic stress effects on memory: Sex differences in performance and monoaminergic activity. Hormones and Behavior; 43: 48–59.

  18. Dubovicky. (2004). Effect of chronic emotional stress on habituation processes in open field in adult rats. New York Academy of Sciences; 1098: 199-206.

  19. Thompson, R., Spencer, W. (1966) Habituation: a model phenomenon for the study of neuronal substrates of behavior. Psychological Review; 73 (1): 16-43

  20. Gould, T. D. (Ed.). (2009). Mood and anxiety related phenotypes in mice: characterization using behavioral tests. New York: Humana Press.

  21. Schrijver, N.C.A., Bahr, N.I., Weiss, I.C. Würbel, H. (2002) Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats. Pharmacol. Biochem. Behav; 73: 209-224.

  22. Ossenkopp y Mazmanian (1985). The principle of aggregation in psychobiological correlational research: an example from the open field test. Animal Learning and Behavior; 13:339-344.

  23. Ferland, J. M. N., Zeeb, F. D., Yu, K., et al. (2014) Greater sensitivity to novelty in rats is associated with increased motor impulsivity following repeated exposure to a stimulating environment: implications for the etiology of impulse control deficits. European Journal of Neuroscience; 40 (12): 3746-3756.

  24. Pleskacheva, M. (1996) Temporal characteristics of grooming in an open field in two strains of rats. International Journal of Comparative Psychology; 9 (3): 105-116.

  25. Barbelivien, A., Herbeaux, K., Oberling, P., Kelche, C., Galani, R., & Majchrzak, M. (2006). Environmental enrichment increases responding to contextual cues but decreases overall conditioned fear in the rat. Behavioural Brain Research; 169 (2): 231-238.

  26. Sequeira-Cordero, A., Mora-Gallegos, A., Cuenca-Berger, P., Fornaguera-Trías, J. (2013) Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotrophin-releasing factor receptor 1 in the nucleus accumbens. Behavioural Brain Research; 252: 77-87.

  27. Zimmermann, A., Stauffacher, M., Langhans, W., Wurbel, H. (2001) Enrichment-dependent differences in novelty exploration in rats can be explained by habituation. Behavioral Brain Research; 121:11-20

  28. Elliott, B., Grunberg, N. (2005) Effects of social and physical enrichment on open field activity differ in male and female Sprague-Dawley rats. Behavioural Brain Research; 187-196

  29. Rankin, A., Barry, B., Clayton, C., et al. (2009) Habituation revisited: An updated and revised description of the behavioral characteristics of habituation. Neurobiology of learning and memory; 92 (2), 135-138.

  30. Shukitt-Hale, B., Casadesus, Josep. (2001) Automated measurement of age-related changes in the locomotor response to environmental novelty and home-cage activity. Mech Ageing Dev.; 122 (15): 1887-97.

  31. Rosenzweig, ES., Barnes, CA. (2003) Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Progress in Neurobiology; 69 (3) 143-179

  32. Olton, D. and Samuelson, R. (1976) Remembrance of places passed: spatial memory in rats. Journal of Experimental Psychology Animal Behavior Processes; 2 (2): 97-116

  33. Görisch J, Schwarting, R. (2006). Wistar rats with high versus low rearing activity differ in radial maze performance. Neurobiol. Learn. & Memory; 86: 175-187.

  34. Hodges H. (1996). Mazes procedures: the radial-arm and water maze compared. Cog. Brain Research; 3: 167-181.

  35. Morris RGM. (2001) Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease. Phil. Trans. R. Sock Lond; 356: 1453-1465.

  36. Harati, H., Majchrzak, M., Cosquer, B., et al. (2009) Attention and memory in aged rats: Impact of lifelong environmental enrichment. Neurobiology of Aging; 32, 718–736.

  37. Caprioli, O, Ghirardi, Giuliani, Ramacci and Angelucci. (1991) Spatial Learning and Memory in the Radial Maze: A longitudinal study in rats from 4 to 25 months of age. Neurobiology of aging; 605-607.

  38. Diamond, M. (2001) Response of the brain to enrichment. Academia Brasileira de Ciencias; 73: 211–220.

  39. Van Praag, H., Kempermann, G., Gage, F. H. (2000) Neural consequences of environmental enrichment. Nature Reviews Neuroscience; 1: 191–198.

  40. Kempermann, G., Jessberger, S., Steiner, B., Kronenberg, G. (2004) Milestones of neuronal development in the adult hippocampus. TRENDS in Neurosciences, 8: 447-452

  41. Luine, V., Bowling, D., and Hearns, M. (1990) Spatial memory deficits in aged rats: contributions of monoaminergic systems. Brain Research; 271-278.

  42. Cohen, M. (2001) An integrative theory of prefrontal cortex function. Annual Review of Neuroscience; 24: 167-202

  43. Arbuthnott, G.W., Ingham, C.A., Wickens, J.R. (2000). Dopamine and synaptic plasticity in the neostriatum. J. Anat.; 196: 587-596.

  44. Bäckmann, Lindenberger, Li, Nyberg. (2010). Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neuroscience and biobehavioral reviews; 670-677.

  45. Lanni, C., Govoni, S., Lucchelli, A., Boselli, C. (2009) Depression and antidepressants: molecular and cellular aspects. Cell. Mol. Life Sci; 66: 2985-3008.

  46. Brioni, J.D. (1993) Role of GABA during the multiple consolidation of memory. Curr. Trends Rev; 28: 3-27.




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