Delgado CBA

Language: Spanish
References: 13
Page: 97-101
PDF size: 217.28 Kb.

ABSTRACT

Membrane assymetry represents a feature of paramount relevance in the physiology of the eukaryote cell since the differential distribution of lipids represents by itself the signaling of specific cellular processes. In order to accomplish the membrane assimetry, the cell is provided with flippases, specialized ATPases moving specific phospholipids from the exoplasmic side to the cytoplasmic side of the membrane bilayer, and with floppases moving phospolipids in the opposite direction. In this work are shown the functions performed by several of these transporters located in the canalicular region of hepatocytes where the synthesis and secretion of bile salts occur. Several mutations in the gene encoding for the flippase ATP8B1 produce different types of cholestasis affecting not only the function of hepatocytes, but extrahepatic functions, for example in the small intestine or inner ear.

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