medigraphic.com
ISSN 0185-3325 (Print)
Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2017, Number 4

<< Back

Salud Mental 2017; 40 (4)

An overview of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer’s disease

Alcalá LR, Morelos SED, Osorio RO, González OJJ

Language: Spanish
References: 33
Page: 171-178
PDF size: 508.69 Kb.


ABSTRACT

Background. Alzheimer’s disease (AD) is the most frequent neurocognitive disorder. It affects 50% to 75% of the cases of dementia, and is characterized by a progressive cognitive decline that hinders behavior and functionality. Its etiology is still uncertain, and the efficiency of treatments is limited. Repetitive transcranial magnetic stimulation (rTMS) has been used as an alternative therapeutic strategy, but the clinical impact on Alzheimer’s disease has hardly been studied. Objective. To describe the effects of rTMS on cognition, the behavioral and psychological symptoms of dementia (BPSD), and functionality, considering the various modes of application. Method. The PubMed, ScienceDirect, and PsycInfo databases were consulted using key words relating to the topic of study. Articles published between 2006 and 2016 were selected. Results. The studies that have assessed the clinical effect of rTMS have used various parameters to stimulate and compare the different cortical areas, principally the dorsolateral prefrontal cortex. A variety of benefits have been proposed for patients with Alzheimer’s disease in cognitive domains such as language and episodic memory, as well as behavior and functionality in everyday activities. Discussion and conclusion. rTMS has been suggested as a possible treatment for AD, and the results indicate the need for further studies with different methodological designs and more participants, in addition to cognitive rehabilitation techniques. The objective is to identify the most efficient parameters for stimulation and to explore new cortical targets.


REFERENCES

  1. Ahmed, M. A., Darwish, E. S., Khedr, E. M., El serogy, Y. M., & Ali, A. M. (2012). Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer’s dementia. Journal of Neurology, 259(1), 83-92. doi:10.1007/s00415-011-6128-4

  2. Anderkova, L., & Rektorova, I. (2014). Cognitive effects of repetitive transcranial magnetic stimulation in patients with neurodegenerative diseases - Clinician’s perspective. Journal of the Neurological Sciences, 339(1-2), 15-25. doi:10.1016/j.jns.2014.01.037

  3. Bentwich, J., Dobronevsky, E., Aichenbaum, S., Shorer, R., Peretz, R., Khaigrekht, M., … Rabey, J. M. (2011). Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer’s disease: a proof of concept study. Journal of Neural Transmission, 118(3), 463- 471. doi:10.1007/s00702-010-0578-1

  4. Brem, A.-K., Schilberg, L., Freitas, C., Atkinson, N., Seligson, E., & Pascual-Leone, A. (2013). Effects of cognitive training and rTMS in Alzheimer’s disease. Alzheimer’s & Dementia, 9(4, Supplement), P664. doi:10.1016/j.jalz.2013.05.1367

  5. Cotelli, M., Calabria, M., Manenti, R., Rosini, S., Zanetti, O., Cappa, S. F., & Miniussi, C. (2011). Improved language performance in Alzheimer disease following brain stimulation. Journal of Neurology, Neurosurgery, and Psychiatry, 82(7), 794-797. doi:10.1136/jnnp.2009.197848

  6. Cotelli, M., Manenti, R., Cappa, S. F., Geroldi, C., Zanetti, O., Rossini, P. M., & Miniussi, C. (2006). Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease. Archives of Neurology, 63(11), 1602-1604. doi:10.1001/archneur.63.11.1602

  7. Cotelli, M., Manenti, R., Cappa, S. F., Zanetti, O., & Miniussi, C. (2008). Transcranial magnetic stimulation improves naming in Alzheimer disease patients at different stages of cognitive decline. European Journal of Neurology, 15(12), 1286-1292. doi: 10.1111/j.1468-1331.2008.02202.x

  8. Cotelli, M., Manenti, R., Zanetti, O., & Miniussi, C. (2012). Non-pharmacological intervention for memory decline. Frontiers in Human Neuroscience, 6(March), 46. doi:10.3389/fnhum.2012.00046

  9. Devi, G., Voss, H. U., Levine, D., Abrassart, D., Heier, L., Halper, J., … Lowe, S. (2014). Open-label, short-term, repetitive transcranial magnetic stimulation in patients with Alzheimer’s disease with functional imaging correlates and literature review. American Journal of Alzheimer’s Disease & Other Dementias, 29(3), 248-255. doi: 10.1177/1533317513517047

  10. Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger- Gateau, P., … Scheltens, P. (2010). Revising the definition of Alzheimer’s disease: a new lexicon. The Lancet Neurology, 9(11), 1118-1127. doi:10.1016/ S1474-4422(10)70223-4

  11. Fitzgerald, P. B., & Daskalakis, Z. J. (2013). Repetitive Transcranial Magnetic Stimulation Treatment for Depressive Disorders A Practical Guide. Heidelberg, Berlín: Springer.

  12. Fonseca, L. M., Navatta, A. C. R., Bottino, C. M. C., & Miotto, E. C. (2015). Cognitive Rehabilitation of Dementia in Adults with Down Syndrome: A Review of Non-Pharmacological Interventions. Dementia and Geriatric Cognitive Disorders Extra, 5(3), 330-340. doi:10.1159/000438858

  13. Freitas, C., Mondragón-Llorca, H., & Pascual-Leone, A. (2011). Noninvasive brain stimulation in Alzheimer’s disease: Systematic review and perspectives for the future. Experimental Gerontology, 46(8), 611-627. doi:10.1016/j.exger. 2011.04.001

  14. Haffen, E., Chopard, G., Pretalli, J. B., Magnin, E., Nicolier, M., Monnin, J., … Vandel, P. (2012). A case report of daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) as an adjunctive treatment for Alzheimer disease. Brain Stimulation, 5(3), 264-266. 10.1016/j.brs.2011.03.003

  15. Higgins, E. S., & George, M. S. (2008). Brain Stimulation Therapies for the Clinicians. Arlington, VA: American Psychiatric Publishing.

  16. Hsu, W. Y., Ku, Y., Zanto, T. P., & Gazzaley, A. (2015). Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer’s disease: a systematic review and meta-analysis. Neurobiology of Aging, 36(8), 2348-2359. doi: 10.1016/j.neurobiolaging.2015.04.016

  17. Innocenti, I., Giovannelli, F., Cincotta, M., Feurra, M., Polizzotto, N. R., Bianco, G., … Rossi, S. (2010). Event-related rTMS at encoding affects differently deep and shallow memory traces. NeuroImage, 53(1), 325-330. doi:10.1016/j.neuroimage. 2010.06.011

  18. Lee, J., Choi, B. H., Oh, E., Sohn, E. H., & Lee, A. Y. (2016). Treatment of Alzheimer’s Disease with Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Journal of Clinical Neurology, 12(1), 57-64. doi:10.3988/jcn.2016.12.1.57

  19. Lefaucheur, J.P., Andre-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., … Garcia-Larrea, L. (2014). Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 125(11), 2150-2206. doi:10.1016/j.clinph.2014.05.021

  20. Manenti, R., Cotelli, M., Robertson, I. H., & Miniussi, C. (2012). Transcranial brain stimulation studies of episodic memory in young adults, elderly adults and individuals with memory dysfunction: A review. Brain Stimulation, 5(2), 103-109. doi:10.1016/j.brs.2012.03.004

  21. McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., … Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s and Dementia, 7(3), 263-269. doi:10.1016/j.jalz.2011.03.005

  22. Miniussi, C., & Ruzzoli, M. (2013). Transcranial stimulation and cognition. Handbook of Clinical Neurology, 116, 739-750. doi:10.1016/B978-0-444-53497- 2.00056-5

  23. Nardone, R., Bergmann, J., Christova, M., Caleri, F., Tezzon, F., Ladurner, G., … Golaszewski, S. (2012). Effect of transcranial brain stimulation for the treatment of Alzheimer disease: A review. International Journal of Alzheimer’s Disease, 2012. doi:10.1155/2012/687909

  24. Nardone, R., Tezzon, F., Höller, Y., Golaszewski, S., Trinka, E., & Brigo, F. (2014). Transcranial magnetic stimulation (TMS)/repetitive TMS in mild cognitive impairment and Alzheimer’s disease. Acta Neurologica Scandinavica, 129(6), 351-366. doi:10.1111/ane.12223

  25. National Institute for Clinical Excellence (NICE). (2011). Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease. NICE Technology Appraisal Guidance, 217.

  26. Prince, M., Wimo, A., Guerchet, M., Gemma-Claire, A., Wu, Y.-T., & Prina, M. (2015). World Alzheimer Report 2015: The Global Impact of Dementia - An analysis of prevalence, incidence, cost and trends. London, England: Alzheimer’s Disease International. Retrieved from https://www.alz.co.uk/research/ WorldAlzheimerReport2015.pdf

  27. Rabey, J. M., Dobronevsky, E., Aichenbaum, S., Gonen, O., Marton, R. G., & Khaigrekht, M. (2013). Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: A randomized, double-blind study. Journal of Neural Transmission, 120(5), 813-819. doi:10.1007/s00702-012-0902-z

  28. Rossi, S., Hallett, M., Rossini, P. M., Pascual-Leone, A., Avanzini, G., Bestmann, S., … Ziemann, U. (2009). Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clinical Neurophysiology, 120(12), 2008-2039. doi:10.1016/j. clinph.2009.08.016

  29. Rotenberg, A., Horvath, J.C., & Pascual-Leone, A. (2014). Transcranial Magnetic Stimulation Series Editor, New York, USA: Springer.

  30. Rutherford, G., Gole, R., & Moussavi, Z. (2013). rTMS as a Treatment of Alzheimer ’ s Disease with and without Comorbidity of Depression : A Review. Neuroscience Journal, 2013. doi:10.1155/2013/679389

  31. Stanzione, P., & Tropepi, D. (2011). Drugs and clinical trials in neurodegenerative diseases. Annali dell’Istituto Superiore di Sanità, 47(1), 49-54. doi:10.4415/ ANN_11_01_11

  32. World Health Organization & Alzheimer’s Disease International (ADI). (2012). Dementia: a public health priority. Demencia. Retrieved from http://apps.who.int/ iris/bitstream/10665/75263/1/9789241564458_eng.pdf?ua=1

  33. Wu, Y., Xu, W., Liu, X., Xu, Q., Tang, L., & Wu, S. (2015). Adjunctive treatment with high frequency repetitive transcranial magnetic stimulation for the behavioral and psychological symptoms of patients with Alzheimer’s disease: a randomized, double-blind, sham-controlled study. Shanghai Archives of Psychiatry, 27(5), 280-288. doi:10.11919/j.issn.1002-0829.215107




2020     |     www.medigraphic.com