Collado CAK, Wong HL, Zaldívar SD

Language: Spanish
References: 0
Page: 1-6
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ABSTRACT

New formulations for α-cyanoacrylate tissue adhesives for soft and hard tissue repair are currently under study with a view to improving their properties, among which are the following: biodegradability, bone biocompatibility, flexibility (in soft tissue applications), ease of application and sterility. The adhesive Tisuacryl contains n-butyl cyanocrylate, does not have a pharmacologically active principle, and is sold without prior sterilization. Its preservation (≤ 5 şC) and transport depend on a temperaturecontrolled supply chain unlike similar internationally marketed products which contain pharmacologically active principles in their formulation, are preserved at ambient temperature and are sold sterile. The purpose of this proposal is to point out the importance of an antimicrobial agent within a cyanoacrylate formulation. This agent will act as an anionic polymerization inhibitor, improving the properties and diversifying the potential uses of the product. A review was conducted of updated bibliography on the topic, including high-impact journals and websites about a commercial adhesive containing diiodomethyl-p-tolylsulfone as antimicrobial agent and anionic polymerization inhibitor.