Modesto SV, Aires TC, Passini SVV, da Cruz SSA, Lemes DM

Language: English
References: 5
Page: 259-262
PDF size: 136.87 Kb.

ABSTRACT

A 76-year-old woman with antecedent of bronchiectasis and productive cough during four months was admitted because of worsening of cough six hours ago. She had been under prolonged broad-spectrum antibiotic therapy without improvement. During admission the chest images and laboratory evaluations established the diagnosis of lung aspergillosis. Chronic pulmonary aspergillosis manifests as cavity, fibrosis, aspergilloma or nodules. The diagnosis depends on typical pulmonary images and microscopy and culture evidence of the fungus or positivity of the specific serologic tests for Aspergillus. It is mandatory to rule out other hypothesis, in special tuberculosis. The role of galactomannan test is also commented.

REFERENCES

1. Denning DW, Cadranel J, Beigelman-Aubry C, et al; European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J 2016;47:45-68. doi: 10.1183/13993003.00583-2015.

2. Dos Santos VM, da Trindade MC, de Souza DW, de Menezes AI, Oguma PM, Nascimento AL. A 76-year-old man with a right lung adenocarcinoma and invasive aspergillosis. Mycopathologia 2013;176(1-2):113-118. doi: 10.1007/s11046-013-9651-2.

3. Muthu V, Behera D, Argawal R. Allergic bronchopulmonary aspergillosis or pulmonary tuberculosis: a case of mistaken identity? Lung India 2015;32(5):529-530. doi: 10.4103/0970-2113.164191.

4. Ambasta A, Carson J, Church DL. The use of biomarkers and molecular methods for the earlier diagnosis of invasive aspergillosis in immunocompromised patients. Med Mycol 2015;53(6):531-557. doi: 10.1093/mmy/myv026.

5. Sun KS, Tsai CF, Chen SC, Chen YY, Huang WC. Galactomannan testing and the incidence of invasive pulmonary aspergillosis: a 10-Year Nationwide population-based study in Taiwan. PLoS One 2016;11(2):e0149964. doi: 10.1371/journal.pone.0149964.