Nguyen TH, Falcón MR, Vázquez RS, Almaguer RT, Tamayo BC, Corrales SR, Escobar CMP, González GA, Gutiérrez GO, Llanes CR

Language: Spanish
References: 0
Page: 1-7
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ABSTRACT

Introduction: stool antigen tests have been considered to be promising for the diagnosis of Helicobacter pylori infection. For their incorporation into medical practice, it is indispensable to demonstrate their accuracy in a study population. Objective: evaluate the diagnostic capacity of the commercial systems ELISA SD and SD BIOLINE, Standards Diagnostics, Korea, in Cuban patients with gastroduodenal symptoms. Methods: an evaluation was conducted of 101 stool samples from patients previously classified as H. pylori positive and negative by reference histological tests and the rapid urease test. Estimation was made of performance parameters for both diagnostic systems using the software EPIDAT 3.1. Results: Sensitivity for the systems ELISA SD and SD BIOLINE was 85.25 % and 75.41 %, respectively. Specificity for both was 92.50 %. Positive and negative predictive values, validity and Youden's indices, and diagnostic reliability were satisfactory for both tests. Conclusions: the systems evaluated were found to have a performance level comparable with histological tests and the rapid urease test for active detection of H. pylori infection. This confirms their usefulness for the diagnosis and timely management of patients without having to use invasive tests.