Sherman M

Language: English
References: 5
Page: 478-479
PDF size: 101.01 Kb.

Text Extraction

The incidence of hepatocellular carcinoma (HCC) is increasing in many Western countries, including the US and Canada. Although this is alarming, more alarming is that HCC can be regarded as the canary in the mine-shaft. HCC is a barometer of liver health in a nation, and the increasing prevalence of HCC in the West is an indicator of the increasing prevalence of late stage and end-stage liver disease. In North America this increase is driven by several factors. First is the aging of the population of individuals with chronic hepatitis B and hepatitis C, and second the increasing prevalence of non-alcoholic fatty liver disease (NAFLD). In North America chronic hepatitis B is largely a disease of immigrants, particularly from high prevalence areas, such as China, Vietnam, Korea, the Philippines and Africa.

REFERENCES

1. Bertuccio P, Turati F, Carioli G, Rodriguez T, La Vecchia C, Malvezzi M, Negri E. Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol 2017. epub before print Mar 21 2017.

2. Joy JB, McCloskey RM, Nguyen T, Liang RH, Khudyakov Y, Olmstead A, Krajden M, et al. The spread of hepatitis C virus genotype 1a in North America: a retrospective phylogenetic study. Lancet Infect Dis 2016; 16: 698-702.

3. Golabi.

4. Available from: https://www.cdc.gov/hepatitis/hcv/ guidelinesc.htm [Accessed May 15, 2017].

5. Canadian Task Force on Preventive Health Care. Recommendations on hepatitis C screening for adults. CMAJ 2017; 189: E594-E604.