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Organo Oficial de la Sociedad Mexicana de Urología

2017, Number 4

Rev Mex Urol 2017; 77 (4)

Radical nephrectomy plus level IV thrombus excision with cardiopulmonary bypass, deep hypothermia, and circulatory arrest: a case report and literature review

Izquierdo-Luna JS, Campos-Salcedo JG, Estrada-Carrasco CE, Torres-Gómez JJ, Hernández-Palacios GA, Díaz-Gómez C

Language: Spanish
References: 11
Page: 307-311
PDF size: 303.91 Kb.


ABSTRACT

Background: Renal cell carcinoma has a unique propensity for vascular invasion. Level IV tumor thrombi require multidisciplinary collaboration. The best strategy for managing such patients is still a subject of debate.
Clinical case: A 56-year-old man presented with typical symptoms of kidney cancer and during work-up a tumor thrombus in the right atrium and pulmonary metastases were detected. A multidisciplinary team performed radical nephrectomy plus resection of the thrombus through cardiopulmonary bypass, deep hypothermia, and circulatory arrest, with excellent patient progression. Treatment with tyrosinekinase inhibitors was then begun and at the 11th month of follow-up, the patient has good quality of life and his disease is stable.
Conclusion: Cytoreductive nephrectomy before systemic therapy is recommended in stage IV patients with a potentially resectable tumor. The role of targeted therapy in histologic results other than clear cell disease is not well defined. Enrollment in clinical trials is the preferred strategy for those types of tumor.


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