2017, Number 5
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Rev Invest Clin 2017; 69 (5)
Human B Regulatory Cells: The New Players in Autoimmune Disease
Maravillas-Montero JL, Acevedo-Ochoa E
Language: English
References: 10
Page: 243-246
PDF size: 210.85 Kb.
ABSTRACT
Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses,
specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently.
These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional
factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in
development B-cell targeted therapies seem to be ideal treatments for different types of diseases such as cancer and allergy. Here,
we discuss the current knowledge on the implication of Bregs in autoimmunity-related diseases, highlighting the importance of
these cells for the development of novel strategies in the treatment of these pathologies.
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