2017, Number 4
Dermatología Cosmética, Médica y Quirúrgica 2017; 15 (4)
Gómez-Ornelas E, Toussaint-Caire S, Arenas R
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ABSTRACTSubcorneal pustular dermatosis (Sneddon-Wilkinson disease) is a rare neutrophilic dermatosis, usually with a benign and recurrent course. Pathogenesis of this disease is not yet fully understood, where there is hyperactivation of neutrophils, as a consequence of some cytokines interactions. It presents clinically with pustules mainly on trunk and intertriginous areas and rarely on acral sites. Histologic sections show subcorneal collections of neutrophils. Sometimes it is associated with other pathologies. Treatment of choice is still dapsone, offering a rapid improvement, however there are refractory cases that may require more aggressive management.