Roig ÁT, Perurena LM, Martínez MG, Barrios RY, Hechavarría CCE, Santurio GA

Language: Spanish
References: 0
Page: 319-329
PDF size: 129.85 Kb.

ABSTRACT

Introduction: invasive neonatal candidiasis is a common cause of morbidity, mortality and long term sequelae. Very low weight neonate is the most affected by this type of germ. Objective: to describe the clinical and epidemiological behavior of invasive candidiasis at the neonatology service. Methods: cross-sectional, descriptive and observational study in which the incidence of candidiasis was determined in 949 neonates requiring intensive care. The Candida species, the sensitivity to some antimycotic drugs and the clinical behavior were also determined in the infected infants. Summary measures, absolute and relative frequencies were used for the statistical analysis. Results: general incidence rate was 1.6 % (15 infected in 949 hospitalized children) and the incidence density was 1.7 per 1 000 patient-days (17 episodes/10 153 days). The mortality rate was 13.3 % (2 out of 15). The highest incidence rate was found in children weighing less than 1 000 g and younger than 30 weeks (10.7 and 10 %, respectively). The average age of diagnosis was 20 days (minimum 6 and maximum 84). Candida parapliposis was the predominant species (70 %, 12 out of 15). The most common clinical sign was altered peripheral perfusion (58.8 %) and the most significant alterations observed at the lab were positive reactive C protein and thrombocytopenia (56 %). Conclusions: incidence of invasive candidiasis in this intensive care unit is low; C. parapsilosis infection predominates and the clinical behavior is similar to that reported worldwide.