Kaysheva AL, Kopylov AT, Pleshakova TO, Iourov IY, Vorsanova SG, Yurov YB, Shchetkin AA, Archakov AI, Ivanov YD

Language: English
References: 0
Page: 2211-2214
PDF size: 246.54 Kb.

ABSTRACT

A comparative panoramic mass spectrometric analysis of serum samples of children suffering from autistic disorders was carried out. Three families were examined, with nine samples distributed in four control samples of healthy parents and five samples of autistic children. In the course of comparative analysis of protein composition of the serum samples, a small group of potential marker proteins for diagnosis was selected, which are not functionally or structurally related to one another. The group included 15 proteins; one of them, LIM domain-containing protein 1, was identified in four out of the five autism depleted serum samples, and the other 14 were identified in three samples. This could be the basis to develop highly sensitive quantitative mass spectrometric SRM methods to detect autism markers in serum.