Abenavoli L

Language: Spanish
References: 11
Page: 826-827
PDF size: 103.73 Kb.

Text Extraction

In the last decades the keyword non-alcoholic fatty liver disease (NAFLD) was increasingly evoked in research frameworks and in clinical practice. NAFLD is an umbrella term that includes different entities, in particular the simple hepatic fat accumulation, non-alcoholic steatohepatitis characterized by steatosis with necroinflammation, fibrosis and finally cirrhosis and its complications. Globally, the NAFLD prevalence among liver diseases and in general population, is recently rising along with its associated conditions, as obesity, insulin resistance, metabolic syndrome and diabetes. This increment is related to dietary habits and the increase of sedentary lifestyle. Its diffusion seems to be pandemic, given that it is beginning to affect also the populations in the developing world and rural areas, due to the spread of Western lifestyle. Even if the real rate of worldwide incidence of NAFLD are not known, is estimated that its prevalence in general population has reached 20-30% in Western Countries and 5-18% in Asia and it is increasing over time. Currently, NAFLD pathogenesis can be explained by a “multiple hit” hypothesis, that considers multiple factors acting together on genetically predisposed subjects, to induce NAFLD development and progression.

REFERENCES

1. Nascimbeni F, Pais R, Bellentani S, Day CP, Ratziu V, Loria P, Lonardo A. From NAFLD in clinical practice to answers from guidelines. J Hepatol 2013; 59: 859-71.

2. Abenavoli L, Milic N, Di Renzo L, Preveden T, Medic- Stojanoska M, De Lorenzo A. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22: 7006-16.

3. Abenavoli L, Greco M, Milic N, Accattato F, Foti D, Gulletta E, Luzza F. Effect of Mediterranean Diet and Antioxidant Formulation in Non-Alcoholic Fatty Liver Disease: A Randomized Study. Nutrients 2017; 9: pii: E870.

4. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M. Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 2014; 9: 126-33.

5. Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism 2016; 65: 1038-48.

6. Zheng X, Ren W, Gong L, Long J, Luo R, Wang Y. The Great Chinese Famine Exposure in Early Life and the Risk of Nonalcoholic Fatty Liver Disease in Adult Women. Ann Hepatol 2017; 16: 901-8.

7. Orozco-Solís R, Matos RJ, Guzmán-Quevedo O, Lopes de Souza S, Bihouée A, Houlgatte R, Manhães de Castro R, et al. Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus. PLoS One 2010; 5: e13537.

8. Li M, Reynolds CM, Segovia SA, Gray C, Vickers MH. Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life. Biomed Res Int 2015; 2015: 437107.

9. Wolfe D, Gong M, Han G, Magee TR, Ross MG, Desai M. Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring. Am J Obstet Gynecol 2012; 207: 308.e1-6.

10. de Luca A, Hankard R, Borys JM, Sinnett D, Marcil V, Levy E. Nutriepigenomics and malnutrition. Epigenomics 2017; 9: 893-917.

11. Wang N, Chen Y, Ning Z, Li Q, Han B, Zhu C, Chen Y, et al. Exposure to Famine in Early Life and Nonalcoholic Fatty Liver Disease in Adulthood. J Clin Endocrinol Metab 2016; 101(5): 2218-25.