Pérez RS, González PG, Rivero VI

Language: Spanish
References: 0
Page: 19-27
PDF size: 148.47 Kb.

ABSTRACT

Introduction: Baclofen is indicated as a muscle relaxant for the relief of severe spasticity and exerts its effects as a selective agonist of the GABA-B receptor.
Objective: To characterize baclofen poisonings according to reports to the Cenatox emergency information service between 2011 and 2015.
Methods: A retrospective observational study with a universe of 16 notifications, in which the health center that attended the patient and province of origin was studied by year of study, age group, gender, circumstances, clinical manifestations and severity of intoxication.
Results: The bigger number of reports and the highest absolute frequencies occurred in the year 2014, there were no differences with regard to sex, although among the men, the accidental cause was predominant, and among women the suicides attemps were predominant. All reports came from secondary care, although five of the patients had previously been assisted in health care areas; all affected had neurological manifestations, most were reported as severe and half of the cases presented cardiorespiratory alterations with hemodynamic instability leading to ventilatory assistance. Recovery was complete in all patients and no deaths were reported for this cause during the study period.
Conclusions: Baclofen overdose was more common in children and was characterized by neurotoxicity and hemodynamic instability.