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ISSN 0185-3325 (Print)
Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2018, Number 1

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Salud Mental 2018; 41 (1)

Correlation between intake of omega-3 fatty acids and depressive and anxiety symptoms during pregnancy

Álvarez-Ramírez M, Lara MA, Cervantes-Alfaro JM, Robinson-Fuentes VA, Alveano-Hernández J

Language: English
References: 42
Page: 31-38
PDF size: 536.09 Kb.


ABSTRACT

Introduction. Anxiety and depression during pregnancy are disabling disorders associated to complications during the pregnancy, delivery, and postpartum period, with a significant prevalence, between 9 and 20%, hence its importance. Nutritional factors, such as omega-3 fatty acids (ω-3FA) deficiency, have been related with both disorders during pregnancy, especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Objective. To evaluate the association between dietary intake of EPA and DHA, and anxiety symptoms (AS) and depressive symptoms (DS) in Mexican pregnant women. Method. The sample consisted of 151 women in the second trimester of pregnancy. Instruments included a Food Frequency Questionnaire, the Trait Anxiety Inventory, and the Edinburgh Postnatal Depression Scale. Results. A daily intake of DHA and EPA of 70 mg/d and 30 mg/d, respectively, was found. The prevalence of AS was 44.4%, and 17.9% for DS. We also found the correlation negatively moderate between dietary intake of DHA and EPA and AS (p = .003, p = .017) and DS (p = .001, p = .020) in the group of women who had a severely insufficient intake of ω-3FA. Discussion and conclusion. The statistical significance shows a negative correlation between variables and the dietary intake of ω-3FA explains in a very small percentage the variability of AS and DS, according to their coefficient of determination. These results suggest the need for an investigation of this relationship through interventional studies.


REFERENCES

  1. Almanza-Muñoz, J., Salas-Cruz, C., & Olivares-Morales, A. (2011). Prevalencia de depresión postparto y factores asociados en pacientes puérperas de la Clínica de especialidades de la Mujer. Revista de Sanidad Militar, 65(3), 78-86.

  2. Alvarado-Esquivel, C., Sifuentes-Álvarez, A., Salas-Martínez, C., & Martínez- García, S. (2006). Validation of the Edinburgh Postpartum Depression Scale in a population of puerperal women in Mexico. Clinical Practice and Epidemiology in Mental Health, 2(33), 1-5, doi: 10.1186/1745-0179-2-33.

  3. Assies, J., Pouwer, F., Lok, A., Mocking, R., Bockting, C., Visser, I., …Schene, A. (2010) Plasma and Erythrocyte Fatty Acids Patterns in Patients with Recurrent Depression: A Matched Case-Control Study. PLOS ONE, 5(5), 1-9.

  4. Bazan, N., Musto, A., & Knott, E. (2011). Endogenous signaling by omega-3 DHA derived mediators sustains homeostatic synaptic and circuitry integrity. Molecular Neurobiology. 44, 216-222.

  5. Bennett, H., Einarson, A., Taddio, A., Koren, G., & Einarson, T. (2004). Depression during pregnancy. Overview of Clinical Factors. Clinical Drug Investigation, 24(3), 157-179.

  6. Berenzon, S., Lara, M. A., Robles, R., & Medina-Mora, M. E. (2013). Depresión: estado del conocimiento y la necesidad de políticas públicas y planes de acción en México. Salud Pública de México, 55(1), 74-80.

  7. Ceballos-Martínez, I., Sandoval-Jurado, L., Jaimes-Mundo, E., Medina-Peralta, G., Madera-Gamboa, J., & Fernández-Arias, Y. F. (2010). Depresión durante el embarazo Epidemiología en mujeres mexicanas. Rev Med Inst Mex Seguro Soc, 48(1), 71-74.

  8. Córdoba-Caro, L. G., Luego, L. M., & García, V. (2012) Adecuación nutricional de la ingesta de los estudiantes de secundaria de Badajoz. Nutrición Hospitalaria, 27(4), 1065-1071.

  9. De Castro, F., Place, J. M., Villalobos, A., & Allen-Leigh, B. (2015) Sintomatología depresiva materna en México: prevalencia nacional, atención y perfiles poblacionales de riesgo. Salud Pública de México, 57, 144-154.

  10. Ding, Z., Wu, Y., Xu, S., Zhu, R., Jia, X., Zhan, S., … Tao, F. (2014). Maternal anxiety during pregnancy and adverse birth outcomes: A systematic review and meta-analysis of prospective cohort studies. Journal of Affective Disorders, 159, 103-110. doi: 10.1016/j.jad.2014.02.027

  11. Fadzil, A., Balakrishnan, K., Razali, R., Sidi, H., Malapan, T., Japaraj, R. P., … Manaf, M. R (2013). Risk factors for depression and anxiety among pregnant women in Hospital Tuanku Bainum, Ipoh, Malaysia. Asia-Pacific Psychiatry, 5(1), 7-13. doi: 10.1111/appy.12036.

  12. Field, T., Diego, M., Hernández-Reif, M., Figueiredo, B., Deeds, O., Ascencio, A., … Kuhn, C. (2010) Comorbid depression and anxiety effects on pregnancy and neonatal outcome. Infant Behavior & Development, 33(1), 23-29.

  13. Field, T. (2011) Prenatal depression effects on early development: A review. Infant Behavior and Development. 34(1), 1-14. doi: 10.1016/j.infbeh.2010.09.008

  14. Gavin, N. I., Gaynese, B. N., Lohr, K. N., Meltzer-Brody, S., Gartlehner, G., & Swinson, T. (2005) Perinatal depression: a systematic review of prevalence and incidence. Obstetrics & Gynecology, 106(5), 1071-1083.

  15. Grosso, G., Galvano, F., Marventano, S., Malaguarnera, M., Bucolo, C., Drago, F., & Caraci, F. (2014). Omega-3 fatty acids and depression: Scientific Evidence and Biological Mechanisms. Hindawi Publishing Corporation. Oxidative Medicine and Cellular Longevity, 313570, 1-16. doi: 10.1155/2014/313570

  16. Hanley, G., & Oberlander, T. (2014). The effect of perinatal exposures on the infant: antidepressants and depression. Best Practice & Research Clinical Obstetrics & Gynaecology, 28(1), 37-48. doi: 10.1016/j.bpobgyn.2013.09.001

  17. Hernández-Ávila, M., Romieu, I., Parra, S., Hernández-Ávila, J. E., Madrigal, H., &Willett,W. (1998). Validity and reproducibility a food frequency questionnaire to assess dietary intake of women living in Mexico City. Salud Publica de México, 40(2), 133-140.

  18. Hibbeln, J. R. (2002). Seafood consumption, the DHA content of mother’s milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. Journal of Affective Disorders, 69(1-3), 15-29.

  19. Hoffmire, C., Block, R., Thevenet-Morrison, K., & van Wijngaarden, E. (2012). Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms. An analysis of the 2005- 2008 National Health and Nutrition Examination Survey. Prostaglandins, Leukotrienes and Essential Fatty Acids, 86(4-5), 155-160. doi: 10.1016/j. plefa.2012.03.003

  20. Lara, M. A. (2014). Perinatal Depression in Mexican Women: Prevalence, Risk Factors, and Prevention of Postpartum Depression. In: K. Wisner, S. Lara-Cinisomo, (Eds.), Perinatal Depression Among Spanish-Speaking and Latin American Women. A Global Perspective on Detection and Treatment (pp. 1-13). New York: Springer. doi: 10.1007/978-1-4614-8045-7

  21. Lara M. A., Navarrete, L., Nieto, L., Barba, J. P., Navarro, J. L., & Lara-Tapia, H. (2015). Prevalence and incidence of perinatal depression and depressive symp toms among Mexican women. Journal of Affective Disorders, 175, 18-24. doi: 10.1016/j.jad.2014.12.035

  22. Li, Y., Dai, Q., Ekperi, L. I., Dehal, A., & Zhang, J. (2011). Fish consumption and severely depressed mood, findings from the first national nutrition follow-up study. Psychiatry Research, 190(1), 103-109. doi: 10.1016/j.psychres.2011.05.012

  23. Liu, J., Green, P., Mann, J., Rapoport. S., & Sublette, E. (2015). Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease. Brain Research, 1597, 220-246. doi: 10.1016/j. brainres.2014.11.059

  24. Markhus, M. W., Skotheim, S., Graff, I. E., Frøyland, L., Braarud H. C., Stormark, J. M., & Malde, M. K. (2013). Low Omega-3 Index in Pregnancy Is a Possible Biological Risk Factor for Postpartum Depression. PLOS ONE, 8(7), 1-12. doi: 10.1371/journal.pone.0067617

  25. Meades, R., & Ayers, S. (2011). Anxiety measures validated in perinatal populations: A systematic review. Journal of Affective Disorders, 133(1-2), 1-15, doi: 10.1016/j.jad.2010.10.009

  26. Mizunoya, W., Ohnuki, K., Baba, K., Miyahara, H., Shimizu, N., Tabata, K., … Ikeuchi, Y. (2013). Effect of dietary fat type on anxiety-like and depression-like behavior in mice. Springer Plus, 2(165), 1-9. doi: 10.1186/2193-1801-2-165

  27. Morse, N. (2012). Benefits of Docosahexaenoic Acid, Folic Acid, Vitamin D and Iodine on Foetal and Infant Brain Development and Function Following Maternal Supplementation during Pregnancy and Lactation. Nutrients, 4(7), 799-840. doi: 10.3390/nu4070799

  28. Navarrete, L. E., Lara, M. A., Navarro, C., Gómez, M. E., & Morales, F. (2012). Factores psicosociales que predicen síntomas de ansiedad postnatal y su relación con los síntomas depresivos en el postparto. Revista de Investigación Clínica, 64(6), 625-633.

  29. Parra, M. S., Schnaas, L., Meydan, M., Perroni, E., Martínez, S., & Romieu, I. (2002). Erythrocyte cell membrane phospholipids levels compared against reported dietary intakes of polyunsaturated FA in pregnant Mexican women. Public Health Nutrition, 5(6a), 931-937. doi:10.1079/PHN2002381

  30. Rahman, A., Fisher, J., Bower, P., Luchters, S., Tran, T., Yasamy, M. T., … Waheed, W. (2013). Interventions for common perinatal mental disorders in women in lowand middle- income countries: a systematic review and meta-analysis. Bulletin of the World Health Organization, 91, 593-601. doi: 10.2471/BLT.12.109819

  31. Ramírez-Silva, I., Villalpando, S., Moreno-Saracho, J., & Bernal-Medina, D. (2011). Fatty acids intake in the Mexican population. Results of the National Nutrition Survey 2006. Nutrition & Metabolism, 8(33), 1-10, doi: 10.1186/1743-7075- 8-33

  32. Rizzo, A. M., Corsetto, P. A., Montorfano, G., Opizzi, A., Faliva, M., Giacosa, A., … Rondanelli, M. (2012). Comparison between the AA/EPa ratio in depressed and non-depressed elderly females: Omega-3 fatty acids supplementation correlates with improved symptoms but does not change immunological parameters. Nutrition Journal, 11(82), 1-11.

  33. Rosario-Juárez, I., Santos-García, R., Lara-Cantú, M. A., & Almanza-Muñoz, J. J. (2009). Consistencia interna y análisis factorial de la Escala de Depresión Postparto de Edimburgo en mujeres mexicanas embarazadas y puérperas. Reporte preliminar. Revista Neurología, Neurocirugía y Psiquiatría, 42(1-4), 1-6.

  34. Rubertsson, C., Hellström, J., Cross, M., & Sydsjö, G. (2014). Anxiety in early pregnancy: prevalence and contributing factors. Archives of Women’s Mental Health, 17(3), 221-228. doi: 10.1007/s00737-013-0409-0

  35. Simopoulos, A. P. (1999). Essential fatty acids in health and chronic disease. The American Journal of Medical Nutrition, 70(3), 560s–569s. doi: 10.1093/ ajcn/70.3.560s

  36. Simopoulos, A. P. (2011). Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain. Molecular Neurobiology, 44(2), 203-215. doi: 10.1007/ s12035-010-8162-0

  37. Spielberger, C., & Díaz-Guerrero, R. (1975). IDARE Inventario de Ansiedad: Rasgo-Estado. Manual e Instructivo. México: El Manual Moderno, 1-28.

  38. Su, K. P., Matsuoka, Y., & Pae, C.U. (2015). Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders. Clinical Psychopharmacology, 13(2), 129-137. doi: 10.9758/cpn.2015.13.2.129

  39. Van Eijsden, M., Hornstra, G., van der Wal, M., Vrijkotte, T., & Bonsel, G. (2008). Maternal ω-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study. The American Journal of Clinical Nutrition, 87(4), 887-95.

  40. Vaz, J., Kac, G., Emmett, P., Davis, J. M., Golding, J., & Hibbeln, J. (2013). Dietary Patterns, ω-3FA tty Acids Intake from Seafood and High Levels of Anxiety Symptoms during Pregnancy Findings from the Avon Longitudinal Study of Parents and Children. PLOS ONE, 8(7), 1-9, doi: 10.1371/journal.pone.0067671

  41. Wisner, K. L., Lara-Cinisomo, S., Pinheiro, E., & Luther, J. (2014). Characteristics of Hispanic Women Screened for Postpartum Depression. In: K. Wisner, S. Lara-Cinisomo (Eds.) Perinatal Depression Among Spanish-Speaking and Latin American Women. A Global Perspective on Detection and Treatment (pp. 1-13), New York: Springer. doi: 10.1007/978-1-4614-8045-7_1

  42. World Medical Association. (2013). Declaración de Helsinki. Principios éticos para las investigaciones con seres humanos. 64ª Asamblea General, Fortaleza, Brasil, octubre de 2013. Retrieved from: https://www.wma.net/es/policies-post/ declaracion-de-helsinki-de-la-amm-principios-eticos-para-las-investigaciones- medicas-en-seres-humanos/




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