Méndez-Sánchez N

Language: Spanish
References: 3
Page: 3
PDF size: 97.05 Kb.

Text Extraction

It was believe that Bile acids (BA) were important for the fat absorption and regulations of the sterol metabolism by their chemical and physical properties. Currently, we know that additionally to those properties, BA have many other physiological functions that are under vigorous investigation. One of them is that BA have signaling capabilities related to the activation of FXR (farnesoid X receptor), CAR (constitutive androstane receptor), PXR (pregnane X receptor), VDR (vitamin D receptor), PPAR-α (peroxisome proliferatoractivated receptor, HNF-α (hepatocyte nuclear receptor factor 4), M-BAR (membrane- type receptor for bile acids; TGR5), and LXR (liver X receptor). Moreover, BA have been implicated in several disease states, such as cholestasis; hepatic and intestinal cancers; non alcoholic fatty liver disease (NAFLD), liver cirrhosis; and diabetes mellitus. This supplement of Annals of Hepatology contains the contributions of the First International Symposium on Bile Acids in Health and Disease held in Mexico City in July 28, 2017. In this symposium, we discuss some interesting topics related with the role BA such as the biology of these compounds.

REFERENCES

1. Shiffka SJ, Kane MA, Swaan PW. Planar bile acids in health and disease. Biochim Biophys Acta 2017; 1859: 2269-76.

2. Alnouti Y. Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification. Tox Sci 2009; 108: 225-46.

3. Hofmann AF. Biliary secretion and excretion in health and disease: current concepts. Ann Hepatol 2007; 6: 15-27.