Hernández PW, Pérez AJL, Amador AA, Santana SR, Lemes RA, Ramos RD

Language: Spanish
References: 0
Page: 148-162
PDF size: 124.45 Kb.

ABSTRACT

Introduction: Protein catabolism is an indicator of the metabolic response to injury.
Objective: To determine the evolution of patients with mechanical invasive ventilation and its possible association with protein catabolism by diagnostic category.
Method: An observational, analytical and prospective study was performed with all patients undergoing mechanical invasive ventilation admitted to Intensive Care from 2001 to 2007 and classified according to the diagnostic category (trauma, clinical and surgical). Body weight was measured at admission. Protein catabolism was evaluated during the first 3 days of admission, with plasma urea, creatinine and urinary urea nitrogen. They were contrasted with the dependent variables: mortality, morbidity and time of mechanical ventilation.
Results: We studied 262 patients; 88 presented trauma, 89 clinical conditions and 85 surgical conditions. Protein catabolism was high in trauma and associated with mortality, multiple organ dysfunction and prolonged mechanical ventilation; in surgical patients was associated with morbidity. The low values of urine creatinine,were associated with the greater mortality, morbidity and the prolonged time of mechanical ventilation.
Conclusions: Protein catabolism was associated with the evolution of the patient with mechanical invasive ventilation, in the trauma and surgical categories. There was no evidence of association in the clinical category.