González GR, Miranda CI, Álvarez PJ

Language: Spanish
References: 0
Page: 14-20
PDF size: 334.67 Kb.

ABSTRACT

Introduction: sickle cell disease is one of the hemoglobinopathies of high frequency autosomal recessive inheritance in the world population. In Cuba, the screening is performed by means of the study of hemoglobin electrophoresis to all pregnant women and subsequently to the children of carrier mothers.
Objective: to describe the results of hemoglobin electrophoresis in children of carrier mothers with hemoglobinopathies SS and SC in Minas de Matahambre.
Methods: a descriptive, cross-sectional and retrospective study was carried out on 59 children of mothers with hemoglobin S and C, underwent hemoglobin electrophoresis at birth in Minas de Matahambre between 2006 and 2016.
Results: the municipal frequency of AS hemoglobinopathies in children of pregnant women was 28.8%; the health area of Minas presented 20.3%, followed by Santa Lucia and Sumidero with 6.7% and 1.6% respectively. The frequency of hemoglobin C carriers was 5.08%. The male sex predominated in children with hemoglobin S and C, and only one female case without prior prenatal diagnosis was found to be ill (SS).
Conclusions: the municipal coverage of sickle cell anemia screening program, the frequency of hemoglobinopathies in children of mothers with hemoglobin S and C, their distribution by sex and health care districts were determined, which allows them to provide genetic counseling and follow-up.