Padrón-González AA, González-Losada C, Dorta-Contreras AJ

Language: Spanish
References: 0
Page: 711-719
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ABSTRACT

Introduction: Neurological manifestations associated to dengue virus are being reported more frequently.
Objective: To identify the neuroimmune response evaluated by Reibergram in patients with neurological manifestations because of dengue virus.
Material and methods: The highest levels of immunoglobulin and albumin were quantified in serum and the cerebrospinal fluid in six adult patients with neurological manifestations of dengue. Q function was calculated with the concentration values in serum and cerebrospinal fluid of these analytes. Values of immunoglobulin Q vs Q albumin were introduced in the specific Reibergrams for each immunoglobulin. Albumin was used as a marker for the evaluation of Blood-Cerebrospinal Fluid barrier.
Results: Reibergram allowed to establish the incidence of intrathecal synthesis of higher immunoglobulins (three types of patterns) in both the postinfectious and parainfectious neurological manifestations, except a patient who developed Guillain-Barre Syndrome. It also allowed to evaluate the blood-cerebrospinal fluid barrier in each patient.
Conclusions: The use of Reibergram is important in the assessment of the immune response in patients with neurological manifestations of dengue virus.