2017, Number 6
Revista Habanera de Ciencias Médicas 2017; 16 (6)
Reno-protective and reno-restorative effect of the Epidermal Growth Factor in the biomodel of Chronic Renal Failure
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ABSTRACTIntroduction: Kidney disease is a health problem worldwide. Epidermal Growth Factor acts as cytoprotector, and trophic restorative.
Objective: To evaluate the reno-protective and reno-restorative effect of the Epidermal Growth Factor in the biomodel of Chronic Renal Failure.
Material and Methods: 120 Wistar rats were studied in 6 groups: Negative and Positive Control, Saline Solution Single-Dose and Multiple-Dose, Epidermal Growth Factor Single- Dose and Multiple-Dose. A single dose was applied before the damage for the reno-protective effect, and multiple doses were applied after the damage for the reno-restorative effect,at a weight ratio of 100 μg/kg.
Results: Creatinine, urea, and uric acid diminished significantly in the experimental groups, with a higher decrease for experimental group with single dose; therefore, the reno-protective effect was higher than the reno-restorative one for the treatment patterns used.
Conclusions: Epidermal Growth Factor showed reno-protective and reno-restorative effect by diminishing the hematological variables of kidney damage.