Boffill CM, Martín CMJ

Language: Spanish
References: 0
Page: 45-52
PDF size: 334.28 Kb.

ABSTRACT

Introduction: in previous works, we have shown experimentally that the green fruit of the Musa spp. ABB, Burro CEMSA variety, is an effective gastroprotective agent.
Objective: to evaluate possible mechanisms by which the pulp of this fruit produces gastroprotection.
Methods: male Wistar rats of 190 ± 10 g were used. The green fruit’s pulp was sliced, dried at 50°C for 72 hours, milled and sieved. Six experimental groups were formed: negative control, positive control and the groups given the banana pulp at a dose of 125; 250; 500 and 1000 mg/kg body weight for 3 days before inducing ulcers in all groups by indomethacin 40 mg/kg body weight. The anti- ulcer effect, myeloperoxidase activity, superoxide dismutase and prostaglandin levels in the gastric mucosa were determined.
Results: a highly significant decrease in the severity of the lesions was obtained with the use of all fruit preparations; a significant decrease of myeloperoxidase was observed only with the dose of 1000 mg/kg body weight, as well as, a significant increase in superoxide dismutase and content of prostaglandin levels in the gastric mucosa was obtained with all doses used.
Conclusion: the preparations from the pulp had a strong gastroprotective action. The mechanism of action is mediated by an antioxidant effect and mucosal protection by increasing prostaglandin levels.