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2018, Number 1

Rev Invest Clin 2018; 70 (1)

Heading toward the elimination of Hepatitis C virus

Kershenobich D, Torre-Delgadillo A, Aguilar-Valenzuela LM
Full text How to cite this article

Language: English
References: 7
Page: 29-31
PDF size: 128.24 Kb.


Key words:

Hepatitis C, Chronic hepatitis, Direct Antiviral Agents, Continuum of care.

ABSTRACT

Chronic hepatitis C is often asymptomatic and may progress over the years to cirrhosis and hepatocellular carcinoma. Although the prevalence and incident cases are decreasing, the peak mortality of hepatitis C virus (HCV)-related complications is ahead of us in most countries. The economic impact of this burden is enormous. Scaling up the identification of new opportunities to facilitate the road toward HCV elimination includes increasing screening, awareness, and the number of prescribing physicians. Screening should occur within the context of linkage-to-care and patient retention across the care continuum. Awareness and access to treatment in different countries are not systematic as countries have diverse healthcare organizations so that treatment eligibility and availability criteria vary significantly. The simplicity of oral regimens with direct-acting antiviral drugs that are effective across HCV genotypes expands the number of physicians who can prescribe them with accessible treatment models. The ultimate aim is the elimination of HCV by 2030.


REFERENCES

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  2. Jackson WE, Everson GT. Sofosbuvir and velpatasvir for the treatment of hepatitis C. Expert Rev Gastroenterol Hepatol. 2017;11:501-5.

  3. Kwo PY, Poordad F, Asatryan A, et al. Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. J Hepatol. 2017;67:263-71

  4. WHO. Hepatitis C Fact Sheet. Updated October, 2017 Geneva: WHO; 2017.

  5. Grebely J, Applegate TL, Cunningham P, Feld JJ. Hepatitis C point-of-care diagnostics: in search of a single visit diagnosis. Expert Rev Mol Diagn. 2017;17:1109-15.

  6. Morgan JR, Servidone M, Easterbrook P, Linas BP. Economic evaluation of HCV testing approaches in low and middle income countries. BMC Infect Dis. 2017;17:697.

  7. Gunter J, Chirino-Sprung RA, Méndez-Sánchez N, et al. Cost Analysis of Strategies to Control the Disease Burden of Chronic Hepatitis C Virus (HCV) Infection in Mexico. AASLD, Poster No. 171003; 2017.




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CÓMO CITAR (Vancouver)

Rev Invest Clin. 2018;70