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2003, Number 1

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Rev Mex Pediatr 2003; 70 (1)

Effect of the direct administration of hyaluronic acid in the regeneration of a sectioned peripheral nerve

Silva CA, Soriano RRE, Beatriz E Pérez Guillé, Sicilia AG, Vigueras VRM, Reyes TG

Language: Spanish
References: 21
Page: 14-18
PDF size: 152.00 Kb.


ABSTRACT

Previous studies have shown the re-establishment of the function of a sectioned sciatic nerve by the application of nerve growth factors that increase the number of axonal connections and the thickness of the myelin sheath. The aim of this study was to assess the regeneration of the sectioned sciatic nerve and its function by the direct application of hyaluronic acid. A total of 45 Wistar rats weighing 250-300 g were used and divided into three groups of 15 rats each. Group 1 was used as the healthy control group, group 2 was administered physiologic saline solution at the plasty site and group 3 received 20% hyaluronic acid on the sectioned area. All groups were subjected to gait tests at 5 weeks. Group 1 showed differences in: sensitivity, tarsal movement, finger opening and grasping compared to groups 2 and 3. The histologic analysis showed that the animals in group 3 had a greater number of axons connected compared with group 2. We believe the direct use of injected hyaluronic acid improves the regeneration process of the sectioned sciatic nerve in the rat.


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