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Órgano Oficial de el Colegio Mexicano de Urología

2007, Number 3

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Bol Col Mex Urol 2007; 22 (3)

Aplicación transuretral de mitomicina C como adyuvante de la uretrotomía interna (UTI)

Castillo GJM, López VJF, Aragón TAR, Camacho TVF, Colorado GA, Vargas VP

Language: Spanish
References: 15
Page: 125-129
PDF size: 241.14 Kb.


ABSTRACT

Introduction: Urethral stricture is an ancient disease with high morbidity and recurrence rate. Internal urethromy is the endoscopically ablation of the stricture with 80% rate of recurrence. Mitomycin is an antineoplastic and antifibrotyc drug, delaying the scar formation, thus, avoid the sctricture recurrence. It is used since several years in ophthalmology and otorhinolaryngology. Objective: Evaluate the results of intraurethral application of mitomycin C 0.1 mg and its efficacy after the internal urethrotomy. Material and Methods: Randomized clinical assay with 27 patients, carrying urethral stenosis, separated in two groups, comparing the symptoms before and after the study and the urethral width in the urethrography. We analyze the results using the chi-square test and Wilcoxon signed rank test. Results: Improvement of symptoms was successfully in the mitomycin group (p = 0.012) vs. without mitomycin. Posterior urethrography shows an improvement (p = 0.013). Conclusions: We propose the application of mitomycin before the internal urethrotomy to prevent the stricture recurrence. Its ease and safety. With previous reports showing this improvement.


REFERENCES

  1. McAninch JW. Disorders of the penis and male urethra. Tanagho EA, McAninch. Smith’s general urology. 16th Ed. New York: McGraw Hill; 2004.

  2. Jordan GH, Scholssberg SM. Surgery of the pens and urethra. Retik AB, Vaughan (eds.). Wein AJ. Campbell’s urology. Philadelphia: Saunders; 2002.

  3. Pansadoro V, Emiliozzi P. Internal urethrotomy in the management of anterior urethral strictures. Long-term followup. J Urol 1996; 156: 73-5.

  4. Milroy E, Chapple CR, Cooper JE, et al. A new treatment for urethral strictures. Lancet 1988; 1: 14-24.

  5. Ashken MH, Coulange C, Milroy EJ, et al. European experience with the urethral wallstent for urethral strictures. Eur Urol 1991: 1; 181.

  6. Sidoti PA, Belmonte SJ, Liebdman JM. Trabeculectomy with mitomicyn C en the treatment of pediatric glaucoma. Am Acad Ophthalmol 2000; 20: 422-8.

  7. Beckers HJ, Kinders KC, Webbers CA. Five Years result of trabeculectomy with mitomicyn C. Graefers Arch Clin Exp Ophthalmol 2003; 241: 106-10.

  8. Yucel OT. Topical use of mitomycin C in laser myringotomy: an experimental study in rats. Int J Pediatr Otorhinolaryngol 2000; 54: 93-6.

  9. Jassir D, Buchman CA, Gomez-Marin O. safety and efficacy of topical mitomycin C in myringotomy patency. Otolaryngol Head Neck Surg 2001; 124: 368-73.

  10. 10.Fontana H, Nuori-Mahdavi K, Caprioli J. trabeculectomy with mitomycin C en pseudophakic patients with openangle glaucoma: outcomes and risk factors for failure. Am J Ophtalmol 2006; 141: 652-9.

  11. 11.Mandal AK, Majji AB, Mandal SP. Mitomycin C augmented trabeculectomy for neovascualr glaucoma. A preliminary report. Indian J Ophthalmol 2002; 50: 287-93.

  12. 12.Estrem SA, Van Leeuwen RN. Use of mitomycin C for maintaining myringotomy patency. Otolaryngol Head Neck Sur-g 2000; 122: 8-10.

  13. 13.Calvacanti A, et al. Ratio type III/type I collagen changes in urethral stricture: a new concept. J Urol 2003; 169(Suppl.): 100.

  14. 14.Mazdak H, Meshki I, Ghassami F. Effect of mitomycin C on anterior urethral stricture. Recurrence after internal urethrotomy. J Eur Urol 2007; 51: 1089-92.

  15. 15.Bradner WT. Mitomycin C: a clinical update. Cancer Treat Rev 2001; 27: 35-50.




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