medigraphic.com
SPANISH

Medicina Interna de México

Colegio de Medicina Interna de México.
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2018, Number 3

<< Back Next >>

Med Int Mex 2018; 34 (3)

Bacteremias en HIV-patients in a third level hospital in Colombia, 2014-2016

Sánchez-Pardo S, Ochoa-Díaz A, Rodríguez R, Rojas EM
Full text How to cite this article

Language: Spanish
References: 17
Page: 366-372
PDF size: 459.09 Kb.


Key words:

Bacteremia, Cross Infection, Enterobacteriaceae, Drug Resistance.

ABSTRACT

Background: Bloodstream infections are a growing problem and currently a threat to public health. Bacteremia accounts for 15% of all nosocomial infections. In patients with HIV, the degree of immunosuppression continues to be the most important risk factor.
Objective: To describe the clinical microbiological and epidemiological characteristics of patients with HIV infection and bacteremia.
Material and Method: A descriptive observational study with patients over 14 years of age with positive blood cultures from the internal medicine service of the Hospital Universitario de Santander, Colombia, between 2014 and 2016, with HIV infection and who met the CDC criteria for torrent infection.
Results: We reviewed 450 records, 44 patients with confirmed diagnosis. 59% were men; the mean age was 42 years. The median of CD4+ T lymphocytes count was 29 cells/mm3, 55.8% had no antiretroviral treatment because they were new diagnoses. The mortality rate was 31.8%. The PITT severity index was classified as mild at 68.1%. The most frequent group of bacteria was the Enterobacteriaceae including K. pneumoniae with 25%. The percentage of resistant germs (E. coli and K. pneumoniae BLEE, P. aeuruginosa MDR, A. baumanii MDR and S. aureus MR) was 26.9%.
Conclusions: The group of patients with HIV in our institution is superior to other series. One in four patients with HIV infection and bacteremia have resistant microorganism.


REFERENCES

  1. Reddy EA, Shaw AV, Crump JA. Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis. Lancet Infect Dis 2010;10: 417-432.

  2. Moon TD, Silva WP, Buene M, Morais L, Valverde E, et al. Bacteremia as a cause of fever in ambulatory, HIVinfected Mozambican adults: Results and policy implications from a prospective observational study. PLoS ONE 2013;8(12):e83591. doi:10.1371/journal.pone.0083591.

  3. García-Gómez M, et al. Bacteriemias por enterobacterias productoras de beta-lactamasas (BLEE, AmpC y carbapenemasas): asociación con los cuidados sanitarios y los pacientes oncológicos. Rev Esp Quimioter 2015;28(5):256-262.

  4. Archibald LK, den Dulk MO, Pallangyo KJ, Reller LB. Fatal Mycobacterium tuberculosis bloodstream infections in febrile hospitalized adults in Dar es Salaam, Tanzania. Clin Infect Dis 1998;26(2):290-296.

  5. Meremo A, Mshana ES, Kidenya BR, Kabangila R, et al. High prevalence of non-typhoid Salmonella bacteraemia among febrile HIV adult patients admitted at a tertiary Hospital, North-Western Tanzania. Int Arch Med 2012;5:28.

  6. Taramasso L, Tatarelli P, Di Biagio A. Bloodstream infections in HIV-infected patients Virulence 2016;7(3):320-328. http://dx.doi.org/10.1080/21505594.2016.1158359.

  7. Zurlo JJ, Lane HC. Chapter 14.4, Other bacterial infections. AIDS: etiology, diagnosis, treatment and prevention. 4th ed. Philadelphia: Lippincott-Raven, 1997;259-265.

  8. Pino M, Erkizia I, Benet S, Erikson E, Fernández-Figueras MT et al, HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells, Retrovirology 2015;12:37. DOI 10.1186/ s12977-015-0160-x

  9. Lee CC, et al. Clinical predictors of the leading pathogens in human immunodeficiency virus-infected adults with community- onset bacteremia in the emergency department: The importance of transmission routes. J Microbiol Immunol Infect 2017. http://dx.doi.org/10.1016/j.jmii.2016.08.001

  10. INSIGHTSTART Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, Sharma S, Avihingsanon A, Cooper DA, F€atkenheuer G, Llibre JM, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 2015;373:795-807; PMID:26192873; http:// dx.doi.org/10.1056/NEJMoa1506816.

  11. Afessa B, Morales I, Weaver B, Bacteremia in hospitalized patients with human immunodeficiency virus: A prospective, cohort study. BMC Infectious Diseases 2001;1:13.

  12. O’Connor J, Vjecha MJ, Phillips AN, Angus B, et al. Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial. Lancet HIV 2017;4:e105-112.

  13. Jacob ST, Pavlinac PB, Nakiyingi L, Banura P, Baeten JM, et al. Mycobacterium tuberculosis bacteremia in a cohort of HIV-infected patients hospitalized with severe sepsis in Uganda–high frequency, low clinical sand derivation of a clinical prediction score. PLoS ONE 2013;8(8):e70305. doi:10.1371/ journal.pone.0070305.

  14. Jaliff BS, Dahl-Knudsen J, Petersen A, Skov R, Benflied T. Outcome and reinfection after Staphylococcus aureus bacteraemia in individuals with and without HIV-1 infection: a case-control study. BMJ Open 2014;4(4):e004075.

  15. Bryce AN, Skittrall JP, Gilleece Y, Sargent C. The changing face of bacteraemia in an HIV-1 positive cohort in the United Kingdom. J Infect 2017;74(3):325-8.

  16. Meyer CN, Skinhoj P, Prag J. Bacteremia in HIV-positive and AIDS patients: incidence, species distribution, risk-factors, outcome, and influence of long-term prophylactic antibiotic treatment. Scand J Infect Dis 1994;26:635e42.

  17. Fondo Colombiano de Enfermedades de Alto Costo. Situación actual del VIH en Colombia 2015 [Internet]. Ministerio de Salud y Protección Social. Colombia;2015. Consultado: [11/01/2018]. Disponible en: https://cuentadealtocosto. org/site/images/Publicaciones/Situacio%CC%81n%20 del%20VIH%20en%20Colombia%202015.pdf




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Med Int Mex. 2018;34