2018, Number 1-2
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ABSTRACTThe term periodontal disease encompasses a wide variety of chronic inflammatory conditions of the periodontium, including gingivitis and periodontitis. Periodontitis is an infectious disease, which occurs due to the progression of untreated gingivitis. It is characterized by a destructive inflammatory process that affects the supporting tissues of the teeth, which causes the loss the teeth. Numerous inflammatory cytokines and mediators contribute to tissue degradation and bone resorption. In the inflammatory process of this disease, there are molecules little studied as a macrophage migration inhibiting factor that is considered an important cytokine of the innate immune system; is expressed constitutively in immune cells and not immune; is released immediately in response to stimuli bacterial, hypoxia and proliferative signals. Previous research has shown that macrophage migration inhibiting factor can participate in the pathophysiology of chronic degenerative and autoimmune diseases; also other studies have shown that macrophage migration inhibiting factor is an enhancer of osteoclastogenesis in periodontitis model in mice. Due to functional characteristics, macrophage migration inhibiting factor may be involved in the immunopathology of periodontal disease.
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