Jaime FJC, Bencomo HA, Sarduy SS, Llerena MD

Language: Spanish
References: 0
Page: 27-36
PDF size: 210.80 Kb.

ABSTRACT

Hematopoietic stem cell transplantation is a potentially curative therapy for patients with various diseases, but only 25-30 % have a compatible donor for human leukocyte antigen. A few years ago it has been developed a transplant with only one identical haplotype; which it is available for most patients, and has been called haploidentical transplantation. There have been attempts to deplete the marrow of T lymphocytes before being infused, mainly due to the presence graft-versus-host disease, and this can lead to primary graft failure and a slow immune recovery. At present, several methods to overcome these drawbacks are made, so this transplantation emerges as an important alternative for those who do not have a fully matched sibling and has the advantage that allows choosing between several candidates and prevents loss of time searching unrelated donor.