Cand HCM, Corrales RRE, Chong LA

Language: Spanish
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ABSTRACT

Introduction: Paraneoplastic neurological syndromes occur before or during the evolution of a cancer and are not related to tumor invasion, ischemia or toxic effects of treatment. They occur in less than 1% of cancer patients, but increase the risk with certain cancers such as small cell lung, breast, ovarian and thymoma. Here we present a 49-year-old man who was admitted for ataxia of rapid installation, chest pain and mediastinal widening whose final diagnosis motivated the review of the literature.
Clinical Case: A 49-year-old patient presented with a dry cough, shortness of breath at rest, and non-oppressive or radiating pain in the anterior thorax. A week later, it was impossible for the patient to take the objects with his hands, to stand up and refer to motor incoordination. Histological study was performed through a biopsy (trucut) of the supraclavicular lymph node, guided by ultrasound, having as diagnosis: classic Hodgkin lymphoma, type 2 scleronodular variety (cellular).
Conclusions: The early diagnosis of paraneoplastic cerebellar degeneration before irreversible neuronal loss seems to be the only factor that can modify the prognosis in these cases.