2018, Number 3
An Med Asoc Med Hosp ABC 2018; 63 (3)
Lima LR, Pérez GA, Duarte CA, Gutiérrez VDH
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ABSTRACTBackground: Rocuronium may produce prolonged muscle relaxation during the anesthetic induction; for this reason, its dose has been reduced with the use of ephedrine to increase its speed of onset and to improve the intubating conditions. The objective was to determine the speed of onset of rocuronium with the use of ephedrine. Material and methods: A clinical, prospective, comparative test was conducted on patients undergoing elective surgery under general anesthesia in the Regional Hospital «Lic. Adolfo Lopez Mateos». The sample was divided into two groups, both received rocuronium bromide 600 µg•kg-1 during the anesthetic induction. One group also received ephedrine plus 75 µg•kg-1 before the induction; the control group was given 5 mL saline 0.9%. The information was analyzed using the SPSS 17.0 software. To compare groups, the Student’s test was applied. Results: We found that the mean blood pressure and heart rate increased in the ephedrine group immediately before and after laryngoscopy. The speed of action of rocuronium was significantly higher (p ‹ 0.05). Conclusions: The use of ephedrine is related to a faster speed of onset of rocuronium.