Borges MY, Borges MY, Agramonte LO, Jerez CAM, Guevara MG, Castelo VX, Valdés MA

Language: Spanish
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ABSTRACT

Introduction: Sickle cell disease is a generic name that is assigned to a group of genetic alterations in which the gene coding for hemoglobin (Hb) S is inherited. It constitutes the most common genetically determined hemolytic anemia in the world, as a clinical expression of chronic organ damage. Cardiovascular alterations contribute to the morbidity and mortality of the adult patient with this entity.
Objective: To determine the alterations of the cardiovascular system in adult patients diagnosed with sickle cell disease treated at the Cardiology and Cardiovascular Surgery Institute from July 2015 to July 2017.
Methods: A descriptive, longitudinal and prospective study was carried out. The sample consisted of 69 patients. The inclusion and exclusion criteria were met and descriptive statistics were used. The results were presented in texts, tables and graphs.
Results: The most affected age group was under 50 years of age in 52.2% while the female gender predominated in 71%. The 33.3% of the patients presented electrocardiographic alterations, of which myocardial ischemia occurred in 15.9%. The calcium score values were normal in 56 patients. The 39.1% presented alterations in the echocardiogram, where mitral valve disease presented in 18.8%.
Conclusions: The highest proportion of patients with SS genotype presented echocardiographic alterations.