Piñol JFN, González FL, Morera PM

Language: Spanish
References: 0
Page: 1-11
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ABSTRACT

Introduction: Scientific evidence supports that elevated levels of bile acids in the intestinal lumen are associated with inflammatory, premalignant and malignant lesions of the colon.
Objective: To scientifically support the condition of elevated levels of total bile acids in faeces, vesicular and cholecystectomized lithiasis as risk factors for colonic lesions.
Method: An analytical research was carried out in the Gastroenterology Institute and the National Center for Minimally-Invasive Surgery, from 2002 to 2015. The study included adults with low digestive symptoms. Two moments were developed: the determination of the relative risk for the presence of colonic lesions diagnosed by endoscopy and the identification by histologic study. Statistical methods were used, such as the Pearson chi-square test, the relative risk determination, logistic regression, among others.
Results: Higher probability was observed for all ages and sexes to present a positive endoscopic and histological diagnosis, in patients with high levels of total bile acids in feces and in cholecystectomized patients. The common and higher relative risks were related to tubular adenomas of high degree of dysplasia and tubulovillous. The most frequent diagnoses were polyps and adenomas.
Conclusions: The results support that high levels of total bile acids in faeces, vesicular lithiasis and being cholecystectomized constitute risk factors for colonic lesions. These three risk conditions are recommended to be included in screening programs for colorectal cancer.