Santos SM, Cabral F, Alves PAD, Lago OD

Language: English
References: 10
Page: 133-136
PDF size: 451.75 Kb.

ABSTRACT

The purpose of this paper is to report a rare form of Brooke-Spiegler syndrome with collision tumor (syringocystadenoma papilliferum with cylindromas). The Brooke-Spiegler syndrome is a genodermatosis of dominant autosomal inheritance. It is characterized by the development of multiple benign tumors of the skin appendages from the change in the sebaceous-apocrine follicular unit. The appendages tumors most commonly found in the syndrome are cylindromas, trichoepitheliomas and eccrine espiroadenomas. We report the case of a 59-year-old male patient, who had had since puberty an onset of papular and nodular lesions in the head, neck and back. This paper highlights the presence of tumor in the collision scalp.

REFERENCES

1. Arretche V, Volá MM, Bazzano C, Agorio C. Síndrome de Brooke-Spiegler. Reporte de un caso y revisión de la literatura. Arch Argent Dermatol. 2015; 65 (2): 60-64.

2. Gerretsen AL, Beemer FA, Deenstra W, Hennekam FA, van Vloten WA. Familial cutaneous cylindromas: investigations in five generations of a family. J Am Acad Dermatol. 1995; 33 (2 Pt 1): 199-206.

3. Parente JNT, Schettini APM, Massone C, Parente RT, Schettini RA. Você conhece esta síndrome? Síndrome de Brooke-Spiegler. An Bras Dermatol. 2009; 84 (5): 547-549.

4. Blake PW, Toro JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat. 2009; 30 (7): 1025-1036.

5. Nagy N, Farkas K, Kinyo A, Nemeth IB, Kis E, Varga J et al. A novel missense mutation of the CYLD gene identified in a Hungarian family with Brooke-Spiegler syndrome. Exp Dermatol. 2012; 21 (12): 967-969.

6. Jordão C, de Magalhães TC, Cuzzi T, Ramos-e-Silva M. Cylindroma: an update. Int J Dermatol. 2015; 54 (3): 275-278.

7. Gerretsen AL, van der Putte SC, Deenstra W, van Vloten WA. Cutaneous cylindroma with malignant transformation. Cancer. 1993; 72 (5): 1618-1623.

8. Retamar RA, Stengel F, Saadi ME, Kien MC, Della-Giovana P, Cabrera H et al. Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol. 2007; 46 (6): 583-586.

9. Durani BK, Kurzen H, Jaeckel A, Kuner N, Naeher H, Hartschuh W. Malignant transformation of multiple dermal cylindromas. Br J Dermatol. 2001; 145 (4): 653-656.

10. Oliveira A, Arzberger E, Zalaudek I, Hofmann-Wellenhof R. Desmoplastic trichoepithelioma and melanocytic nevus: dermoscopic and reflectance confocal microscopy presentation of a rare collision tumor. J Am Acad Dermatol. 2015; 72 (1 Suppl): S13-S15.