Blanco SMJ

Language: Spanish
References: 2
Page: 59-60
PDF size: 415.51 Kb.

ABSTRACT

Phospholipids can get organized in microdomains known as lipid rafts, which are highly dynamic and can, among other functions, work as platforms of receptors to allow signal transduction. sKL is the extracellular domain of a membrane protein and is released under different cellular conditions. In 2017, Dalton and his collaborators reported a brand-new function in cellular signaling: the reorganization of lipid rafts caused by the union of sKL to gangliosides containing sialic acid with a glycosidic bond α2g3.

REFERENCES

1. Pallavi V, Vikas Y, Neeru S (2016) Lipid rafts in immune signalling: current progress and future perspective. Immunology 149(1): 13–24.

2. Dalton G, An S, Al-Juboori SI, Nischan N, Yoon J, Dobrinskikh E, Hilgemann D, Xie J, Phelps K, Kohler JJ, Birnbaumer L, Huang C (2016) Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling. PNAS 114(4): 752–757