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Federación Mexicana de Ginecología y Obstetricia, A.C.

2018, Number 09

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Ginecol Obstet Mex 2018; 86 (09)

Correlation of uric acid and serum creatinine in pregnant patients with severe preeclampsia

Vázquez-Rodríguez JG, Isla-Arias MX

Language: Spanish
References: 17
Page: 567-574
PDF size: 303.02 Kb.


ABSTRACT

Objective: To determine the correlation of uric acid and creatinine in pregnant patients with severe preeclampsia to identify its clinical utility.
Material and Method: cross-sectional study that included 100 pregnant patients with severe preeclampsia. Blood levels of uric acid and creatinine were recorded upon admission to calculate the correlation of the general means and by categories. (Normal uric acid ≤ 4 mg/dL, hyperuricemia › 4 mg/dL and extreme hyperuricemia ≥7 mg/dL vs normal creatinine ≤ 0.9 mg/dL, hyperazotemia › 0.9 mg/dL and extreme hiperazoemia ≥ 1.1 mg/dL). Descriptive statistics, Student's T-test, Confidence intervals (CI) and Pearson's correlation coefficient were used with the statistical program SPSS version 20.
Results: 100 patients with severe preeclampsia were studied. The general average of uric acid was 5.52 ± 1.43 mg / dL; 85% had hyperuricemia and 17% extreme hyperuricemia. The general average of creatinine was 0.77 ± 0.25 mg / dL; 18% resulted with hyperazotemia and 14% with extreme azotemia.
Conclusions: Uric acid and creatinine showed positive correlations. It was found that the greater the degree of hyperuricemia, the greater the deterioration of renal function. Both markers can be complemented to identify acute kidney injury in severe preeclampsia.


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