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>Journals >Cirujano General >Year 2018, Issue 2

Moreno-Paquentín E, Caba MD, Sánchez-García J, Arrangoiz-Majul R, Cordera-González CF, Luque LE, Muñoz-Juárez M, Cruz-González E, Negrete-Cervantes LF, Valdez-Bocanegra DR, Tamayo-Ochoa P
Case report of a giant gastrointestinal stromal tumor and review of the literature
Cir Gen 2018; 40 (2)

Language: Español
References: 22
Page: 127-132
PDF: 240.53 Kb.

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Introduction: Gastrointestinal stromal tumors (GIST) represent a group of non-epithelial rare tumors with an estimated incidence of 10 to 20 per million persons. GISTs can present at any age but more commonly in persons between ages of 40 and 70 years. They arise more frequently from the stomach and have Kit gene mutation. Material and methods: We presented a case of a 39-year old male with a giant abdominal tumor with surgical resection and review of the literature of GIST. Results: A wedge resection of a GIST measuring 49 × 45 × 15 cm was performed. Microscopically, it was a spindle-shaped tumor cells GIST, low-grade histology (1), pT4 (more than 10 cm), with an intermediate risk (mitotic count less than 5 per 50 HPF and more than 10 cm) and complete resection (R0). Conclusion: In this case, we describe the clinical presentation and the diagnosis algorithm of a low grade giant gastric GIST. To our knowledge, this could represent the biggest GIST reported in the literature.

Key words: Gastrointestinal stromal tumor, GIST, surgical oncology, CARE.


  1. Wang Y, Peng J, Huang J. Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: a case report. Oncol Lett. 2016; 11: 2035-2038. [Internet] [Citado el 30 de marzo de 2017]. Disponible en: http://www.spandidos-publications.com/10.3892/ol.2016.4196

  2. Miyazaki R, Arihiro S, Hayashi E, Kitahara T, Oki S, Kamba S, et al. A giant gastrointestinal stromal tumor of the stomach with extramural growth. Case Rep Gastroenterol. 2016; 10: 344-351.

  3. Sorour MA, Kassem MI, Ghazal AE-HA, El-Riwini MT, Abu Nasr A. Gastrointestinal stromal tumors (GIST) related emergencies. Int J Surg. 2014; 12: 269-280.

  4. Nemeth K, Williams C, Rashid M, Robinson M, Rasheed A. Oesophageal GIST—A rare breed case report and review of the literature. Int J Surg Case Rep. 2015; 10: 256-259.

  5. Poveda A, García del Muro X, López-Guerrero JA, Cubedo R, Martínez V, Romero I, et al. GEIS guidelines for gastrointestinal sarcomas (GIST). Cancer Treat Rev. 2017; 55: 107-119.

  6. Agha RA, Fowler AJ, Saeta A, Barai I, Rajmohan S, Orgill DP, et al. The SCARE Statement: Consensus-based surgical case report guidelines. Int J Surg. 2016; 34: 180-186.

  7. Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol. 1983; 7: 507-519.

  8. Zeng S, Seifert AM, Zhang JQ, Cavnar MJ, Kim TS, Balachandran VP, et al. Wnt/β-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor. Mol Cancer Ther. 2017; 16: 1954-1966.

  9. Geddert H, Braun A, Kayser C, Dimmler A, Faller G, Agaimy A, et al. Epigenetic regulation of CD133 in gastrointestinal stromal tumors. Am J Clin Pathol. 2017; 147: 515-524.

  10. Patil S, Jain S, Kaza RC, Chamberlain RS. Giant gastrointestinal stromal tumor presenting as a palpable abdominal mass: an unusual presentation. ISRN Surg. 2011; 2011: 894829.

  11. Zhou L, Liu C, Bai JG, Wei JC, Qu K, Tian F, et al. A rare giant gastrointestinal stromal tumor of the stomach traversing the upper abdomen: a case report and literature review. World J Surg Oncol. 2012; 10: 66.

  12. Martin-Broto J, Martinez-Marín V, Serrano C, Hindi N, López-Guerrero JA, Ramos-Asensio R, et al. Gastrointestinal stromal tumors (GISTs): SEAP–SEOM consensus on pathologic and molecular diagnosis. Clin Transl Oncol. 2017; 19: 536-545. [Internet]. [Citado el 31 de marzo de 2017]. Disponible en: http://link.springer.com/10.1007/s12094-016-1581-2

  13. Misawa S, Takeda M, Sakamoto H, Kirii Y, Ota H, Takagi H. Spontaneous rupture of a giant gastrointestinal stromal tumor of the jejunum: a case report and literature review. World J Surg Oncol. 2014; 12: 153.

  14. Bara T, Jung I, Gurzu S, Kadar Z, Kövecsi A, Bara Jr T. Giant gastrointestinal stromal tumor of the stomach: a challenging diagnostic and therapeutically approach. Rom J Morphol Embryol. 2015; 56: 1503-1506.

  15. Sun K, Xu S, Chen J, Liu G, Shen X, Wu X. Atypical presentation of a gastric stromal tumor masquerading as a giant intraabdominal cyst: a case report. Oncol Lett. 2016; 12: 3018-3020. [Internet]. [Citado el 8 de mayo de 2017]; Disponible en: http://www.spandidos-publications.com/10.3892/ol.2016.4968

  16. Dal Corso HM, Solej M, Nano M. Giant gastrointestinal stromal tumor of the stomach in an elderly patient. J Gastrointest Surg. 2007; 11: 804-806.

  17. Vinagreiro M, Valverde JN, Guerreiro E. Initial presentation of a giant gastrointestinal stromal tumour of the stomach with recurrent spontaneous intra-peritoneal haemorrhage. Int J Surg Case Rep. 2015; 9: 1-4.

  18. Schneider C, Hewin DF. Resection of giant gastric GIST with a new generation ultrasonic scalpel device. World J Clin Cases. 2014; 2: 9-11.

  19. Fukuda S, Fujiwara Y, Wakasa T, Kitani K, Tsujie M, Yukawa M, et al. Giant gastric gastrointestinal stromal tumor with severe peritoneal dissemination controlled by imatinib therapy following debulking surgery: a case report. J Med Case Reports. 2017; 11: 33. [Internet] [Citado el 30 de marzo de 2017]. Disponible en: http://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-017-1215-5

  20. Navarrete A, Momblán D, Almenara R, Lacy A. Giant gastric gastrointestinal stromal tumor (GIST). J Gastrointest Surg. 2017; 21: 202-204.

  21. Schmieder M, Henne-Bruns D, Mayer B, Knippschild U, Rolke C, Schwab M, et al. Comparison of different risk classification systems in 558 patients with gastrointestinal stromal tumors after r0-resection. Front Pharmacol. 2016; 7: 504. [Internet]. [Citado el 31 de marzo de 2017]. Disponible en: http://journal.frontiersin.org/article/10.3389/fphar.2016.00504/full

  22. Cappellani A, Piccolo G, Cardì F, Cavallaro A, Menzo EL, Cavallaro V, et al. Giant gastrointestinal stromal tumor (GIST) of the stomach cause of high bowel obstruction: surgical management. World J Surg Oncol. 2013; 11: 172.

>Journals >Cirujano General >Year 2018, Issue 2

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