2018, Number 3
Rev Hematol Mex 2018; 19 (3)
Estrada-Rivera EL, Mares-Gil JE, Gómez-González D, Colunga-Pedraza J, Velasco-Ruiz I, Jiménez-Antolinez V, González-Llano O
PDF size: 214.27 Kb.
ABSTRACTHodgkin’s lymphoma is often associated with paraneoplastic syndromes, of these, renal involvement is one of the least frequent associations, particularly nephrotic syndrome. In children a low incidence is reported ranging from 0.6 to 1% in other countries. In Latin-American pediatric population there is a limited number of reports about the Hodgkin’s lymphoma and nephrotic syndrome association. In this article we discuss the case of a 5-year-old patient who developed clinical features of renal failure consistent with nephrotic syndrome, receiving treatment without significant improvement, prior to be diagnosed with Hodgkin’s lymphoma. We describe his evolution, treatment y current state. A clear physiopathology of the association between Hodgkin’s lymphoma and renal lesion has not been established; it has been linked to a disruption in the glomerular basement membrane permeability caused by T-cell dysfunction and abnormal cytokine production. In the Hodgkin’s lymphoma associated with nephrotic syndrome cases, patient evolution and prognosis depend on response to treatment of Hodgkin’s lymphoma. Hodgkin’s lymphoma and nephrotic syndrome association in pediatric patients is rare, so that in atypical presentations of nephrotic syndrome, steroid resistance or early relapse is important having it in mind.