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Órgano Oficial de la Asociación Dental Mexicana

2006, Number 3

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Rev ADM 2006; 63 (3)

In vitro comparison of the effectiveness on antibiotics against facultative anaerobic bacteria isolated from infected root canals

Paniagua CGL, Monroy PE, Juárez AI, Furuya MAT, Vaca PS, Aguilar EL, Gómez MA, González ASE

Language: Spanish
References: 20
Page: 103-110
PDF size: 146.30 Kb.


ABSTRACT

The aim of this study was to compare the effectiveness of antibiotics against facultative anaerobic bacteria isolated from patients with infected root canals. Bacteria were identified by the API-STAPH, API-20E, API 20 NE and API Candida systems. Minimal inhibitory concentrations (MIC) of penicillin, ampicillin, amoxicillin, ceftazidime, oxytetracycline, clindamycin, cefotaxime and ampicillin plus sulbactam were determined by plate dilution. Forty two facultative anaerobic microorganisms were identified. All Grampositive bacteria were resistant to penicillin (MIC90 =143.85 µg/mL), ampicillin (MIC90 = 58.45 µg/mL), and clindamycin (MIC90 = 225 µg/mL), but sensitive to cefotaxime (MIC90 = 1.71 µg/mL) and to ampicillin plus sulbactam (MIC90 = 1.62 µg/mL). One hundred percent Gramnegative bacteria were resistant to penicillin (MIC90 = 225 µg/mL), ampicillin (MIC90 = 67.94 µg/mL), amoxicillin (MIC90 = 225 µg/mL), oxytetracycline (MIC90 = 28.11 µg/mL) and clindamicyn (MIC90 = 225 µg/mL), but sensitive to cefotaxime (MIC90 = 1.79 µg/mL) and to ampicillin plus sulbactam (MIC90 = 1.83 µg/mL). These results showed that cefotaxime and the combination ampicillin plus sulbactam represent a good choice for treatment of root canals bacterial infections.


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