Cicero-Sabido R, Meléndez-Mier G

Language: Spanish
References: 7
Page: 620-621
PDF size: 118.62 Kb.

ABSTRACT

The appearance of new anti-tuberculosis drugs such as bedaquiline and delamanid makes it impossible not to remember that the first strictly controlled medical trials of tuberculosis treatment were published in two rigorously researched outstanding articles that can be qualified as historical. In 1948, streptomycin was formally studied as an efficacious anti-tuberculosis drug. In 1952, another trial compared streptomycin-paramino salicylic acid with isoniazid, by means of which the first bases of pharmacological tuberculosis treatment were established.

REFERENCES

1. Bayfield A, editor. Martindale. The complete drug reference. Pharmaceutical Press: Londres; 2014.

2. Streptomycin treatment of pulmonary tuberculosis. A medical research council investigation. Br Med J. 1948;2(4582):769-782.

3. TREATMENT of pulmonary tuberculosis with isoniazid; an interim report to the Medical Research Council by their Tuberculosis Chemotherapy Trials Committee. Br Med J. 1952;2(4787):735-746.

4. Chalmers I. Why the 1948 MRC trial of streptomycin used treatment allocation based on random numbers. J R Soc Med. 2011;104(9):383-386.

5. Michinson D, Davies G. The chemotherapy of tuberculosis: past, present and future. Int J Tuberc Lung Dis. 2012;16(6):724-732.

6. World Health Organization. Global tuberculosis report 2015. Suiza: World Health Organization; 2016.

7. Ross A, Rosenberg P, Dye C, Prasad A. A world cities and the end of TB. Trans R Soc Trop Med Hyg. 2016;110(3):151-152.