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ISSN 0001-0944 (Print)
Órgano Oficial de la Asociación Dental Mexicana

2018, Number 6

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Rev ADM 2018; 75 (6)

Immunoexpression comparison receptors CD68, in giant and mononuclear cells of central and peripheral giant cell lesions of jaws

de la Rosa-García E, Chávez-Yáñez HE, Noya-Maiz N

Language: Spanish
References: 32
Page: 309-315
PDF size: 353.60 Kb.


ABSTRACT

Introduction: Central (CGCL) and Peripheral (PGCL) giant cell lesions of jaws are reactive lesions displaying different behavior patterns. Objective: To compare CD68 immunoexpression between CGCL and PCGL in giant multinucleated and mononuclear cells. Material and methods: 35 CGCL and 24 PGCL were retrieved from paraffin-embedded biopsy, as well as the feasibility to analyze CD68 immunoexpression. The immunoexpression was analyzed in cytoplasm both cell populations cellular, for and staining intensity was categorized as intense, moderate or faint. Proportions were compared by χ2, making a p ≤ 0.05 value significate. Results: In 96% of CGCL’s in GMCs displayed CD68, as compared to 84.2% in PGCL, (p ‹ 0.005). The proportion of stained cells, intense to moderate staining was more frequent in CGCL (p = 0.032). The proportion CD68 was expressed in 59.3% or CGCL mononuclear cells, as compared to 18.6% in PGCL, (p ‹ 0.001). There was difference in staining CD68 intensity between mononuclear cells in CGCL, (p = 0.002). Conclusions: The high CD68 expression frequency in GMCs and mononuclear cells in central and peripheral GCL confirm a macrophage phenotype; a more intense staining in CGML and GMCs suggests a more active phagocytic activity, and possibility underline the different clinical behavior.


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